Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Yuan Xiong; Bo-Bin Mi; Ze Lin; Yi-Qiang Hu; Le Yu; Kang-Kang Zha; Adriana C. Panayi; Tao Yu; Lang Chen; Zhen-Ping Liu; Anish Patel; Qian Feng; Shuan-Hu Zhou; Guo-Hui Liu

doi:10.1186/s40779-022-00426-8

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Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

REVIEW | Updated：2023-09-05

- Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
- Military Medical Research Vol. 10, Issue 4, Pages: 499-528(2023)
- Affiliations：
  
  1.Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  2.Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China
  3.Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA
  4.Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China
  5.Department of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02152, USA
  6.Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  7.Department of Physics, Center for Hybrid Nanostructure (CHyN), University of Hamburg, Hamburg 22761, Germany
  8.Joint Laboratory of Optofluidic Technology and System, National Center for International Research on Green Optoelectronics, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
  9.Skeletal Biology Laboratory, Department of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02120, USA
  10.Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
- Author bio：
  
  * qianfeng@cqu.edu.cn;
  szhou@bwh.harvard.edu;
  liuguohui@hust.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00426-8
  CLC：
- Published：2023-08
- Accepted：
Scan QR Code
Xiong Y, Mi BB, Lin Z, Hu YQ, Yu L, Zha KK, et al. Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res. 2022;9(1):65.
DOI：

Xiong Y, Mi BB, Lin Z, Hu YQ, Yu L, Zha KK, et al. Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res. 2022;9(1):65. DOI： 10.1186/s40779-022-00426-8.

摘要

Abstract

Bone

cartilage

and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types

whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone

cartilage

and soft tissue regeneration

effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone

cartilage

and soft tissue regeneration; therefore

an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable. Herein

we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone

cartilage

and soft tissue repair and regeneration. We discuss the roles of various immune cell subsets in bone

cartilage

and soft tissue repair and regeneration processes and introduce novel strategies

for example

biomaterial-targeting of immune cell activity

aimed at regulating healing. Understanding the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone

cartilage

and soft tissue regeneration through regulation of the immune microenvironment.

关键词

Keywords

references

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