Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Qian Hu; Shu Zhang; Yue Yang; Jia-Qi Yao; Wen-Fu Tang; Christopher J. Lyon; Tony Ye Hu; Mei-Hua Wan

doi:10.1186/s40779-022-00417-9

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Extracellular vesicles in the pathogenesis and treatment of acute lung injury

REVIEW | Updated：2023-09-05

- Extracellular vesicles in the pathogenesis and treatment of acute lung injury
  Enhanced Publication
- Military Medical Research Vol. 10, Issue 4, Pages: 478-498(2023)
- Affiliations：
  
  1.Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
  2.Department of Emergency Medicine, Emergency Medical Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China
  3.Center of Cellular and Molecular Diagnosis, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA 70112, USA
  4.Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA 70112, USA
  5.West China Hospital (Airport) of Sichuan University, Chengdu 610299, China
- Author bio：
  
  * Tonyhu@tulane.edu;
  wanmh@scu.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00417-9
  CLC：
- Published：2023-08
- Accepted：
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Hu Q, Zhang S, Yang Y, Yao JQ, Tang WF, Lyon CJ, et al. Extracellular vesicles in the pathogenesis and treatment of acute lung injury. Mil Med Res. 2022;9(1):61.
DOI：

Hu Q, Zhang S, Yang Y, Yao JQ, Tang WF, Lyon CJ, et al. Extracellular vesicles in the pathogenesis and treatment of acute lung injury. Mil Med Res. 2022;9(1):61. DOI： 10.1186/s40779-022-00417-9.

摘要

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening lung diseases associated with acute and severe inflammation. Both have high mortality rates

and despite decades of research on clinical ALI/ARDS

there are no effective therapeutic strategies. Disruption of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and injury. Recently

studies on the role of extracellular vesicles (EVs) in regulating normal and pathophysiologic cell activities

including inflammation and injury responses

have attracted attention. Injured and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes

which can be used to diagnose and predict the development of ALI/ARDS. EVs secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function

and thereby promote cell proliferation and tissue regeneration. This review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation

particularly ALI/ARDS.

关键词

Keywords

references

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