Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine

Xing Huang; Gang Zhang; Tian-Yu Tang; Xiang Gao; Ting-Bo Liang

doi:10.1186/s40779-022-00416-w

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Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine

REVIEW | Updated：2023-09-05

- Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine
- Military Medical Research Vol. 10, Issue 4, Pages: 461-477(2023)
- Affiliations：
  
  1.Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  2.Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  3.Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou 310003, China
  4.The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou 310009, China
  5.Cancer Center, Zhejiang University, Hangzhou 310058, China
- Author bio：
  
  * huangxing66@zju.edu.cn;
  liangtingbo@zju.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00416-w
  CLC：
- Published：2023-08
- Accepted：
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Huang X, Zhang G, Tang TY, Gao X, Liang TB. Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine. Mil Med Res. 2022;9(1):53.
DOI：

Huang X, Zhang G, Tang TY, Gao X, Liang TB. Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine. Mil Med Res. 2022;9(1):53. DOI： 10.1186/s40779-022-00416-w.

摘要

Abstract

Pancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity

especially in genetic alteration and microenvironment. Conventional therapeutic strategies for pancreatic cancer usually suffer resistance

highlighting the necessity for personalized precise treatment. Cancer vaccines have become promising alternatives for pancreatic cancer treatment because of their multifaceted advantages including multiple targeting

minimal nonspecific effects

broad therapeutic window

low toxicity

and induction of persistent immunological memory. Multiple conventional vaccines based on the cells

microorganisms

exosomes

proteins

peptides

or DNA against pancreatic cancer have been developed; however

their overall efficacy remains unsatisfactory. Compared with these vaccine modalities

messager RNA (mRNA)-based vaccines offer technical and conceptional advances in personalized precise treatment

and thus represent a potentially cutting-edge option in novel therapeutic approaches for pancreatic cancer. This review summarizes the current progress on pancreatic cancer vaccines

highlights the superiority of mRNA vaccines over other conventional vaccines

and proposes the viable tactic for designing and applying personalized mRNA vaccines for the precise treatment of pancreatic cancer.

关键词

Keywords

references

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