The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer

Zaid Sirhan; Anita Thyagarajan; Ravi P. Sahu

doi:10.1186/s40779-022-00401-3

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The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer

REVIEW | Updated：2023-02-28

- The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer
- Military Medical Research Vol. 9, Issue 5, Pages: 628-636(2022)
- Affiliations：
  
  Department of Pharmacology and Toxicology, Boonshoft School of Medicine Wright State University, Dayton, OH 45435, USA
- Author bio：
  
  * ravi.sahu@wright.edu
- Funds：
- DOI：10.1186/s40779-022-00401-3
  CLC：
- Published：2022-10
- Accepted：
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Sirhan Z, Thyagarajan A, Sahu RP. The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer. Mil Med Res. 2022;9(1):39.
DOI：

Sirhan Z, Thyagarajan A, Sahu RP. The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer. Mil Med Res. 2022;9(1):39. DOI： 10.1186/s40779-022-00401-3.

摘要

Abstract

Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15%–20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase kinase activity

and its overexpression is linked to poor prognosis and shorter progression-free survival (PFS) and overall survival (OS). Among various treatment options

HER2-targeting monoclonal antibodies and tyrosine kinase inhibitors (TKIs) have mostly been applied in recent decades to treat HER2-positive (HER2

) breast cancer patients. Although positive clinical outcomes were documented in both advanced disease and neoadjuvant settings

the development of resistance mechanisms to such approaches has been one of the major challenges with the continuous usage of these drugs. In addition

patients who experience disease progression after treatment with multiple HER2-targeted therapies often have limited treatment options. The Food and Drug Administration (FDA) has recently approved a new TKI (i.e.

tucatinib) for use in combination with immunotherapy and/or chemotherapeutic agents for the treatment of advanced-stage/metastatic HER2

breast cancer. This review highlights recent updates on the efficacy of tucatinib-based therapeutic approaches in experimental models as well as in the clinical settings of HER2

breast cancer.

关键词

Keywords

references

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