mRNA vaccine development for cholangiocarcinoma: a precise pipeline

Tian-Yu Tang; Xing Huang; Gang Zhang; Ming-Hao Lu; Ting-Bo Liang

doi:10.1186/s40779-022-00399-8

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mRNA vaccine development for cholangiocarcinoma: a precise pipeline

PERSPECTIVE | Updated：2023-05-10

- mRNA vaccine development for cholangiocarcinoma: a precise pipeline
- Military Medical Research Vol. 10, Issue 2, Pages: 262-267(2023)
- Affiliations：
  
  1.Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  2.Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  3.Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou 310003, China
  4.Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou 310009, China
  5.Cancer Center, Zhejiang University, Hangzhou 310058, China
- Author bio：
  
  * huangxing66@zju.edu.cn;
  liangtingbo@zju.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00399-8
  CLC：
- Published：2023-04
- Accepted：
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Cite this article as: Tang TY, Huang X, Zhang G, Lu MH, Liang TB. mRNA vaccine development for cholangiocarcinoma: a precise pipeline. Mil Med Res. 2022;9(1):40.
DOI：

Cite this article as: Tang TY, Huang X, Zhang G, Lu MH, Liang TB. mRNA vaccine development for cholangiocarcinoma: a precise pipeline. Mil Med Res. 2022;9(1):40. DOI： 10.1186/s40779-022-00399-8.

摘要

Abstract

Cholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments

including immune checkpoint blockade therapy. The mRNA vaccine-based immunotherapeutic strategy has attracted much attention for various diseases

however

its application in CHOL is limited due to the thoughtlessness in the integration of vaccine design and patient selection. A recent study established an integrated path for identifying potent CHOL antigens for mRNA vaccine development and a precise stratification for identifying CHOL patients who can benefit from the mRNA vaccines. In spite of a promising prospect

further investigations should identify immunogenic antigens and onco-immunological characteristics of CHOL to guide the clinical application of CHOL mRNA vaccines in the future.

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references

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