Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing

Xiao-Xuan Lei; Liu Hang-Hang Cheng; Hai-Yan Lin; Yu Yang; Yun-Yu Lu; Meng-Ru Pang; Yun-Qing Dong; Floris J. Bikker; Tymour Forouzanfar; Biao Cheng; Gang Wu

doi:10.1186/s40779-022-00398-9

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Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing

LETTER TO THE EDITOR | Updated：2023-09-05

- Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing
- Military Medical Research Vol. 10, Issue 4, Pages: 563-566(2023)
- Affiliations：
  
  1.Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Amsterdam Movement Science, 1081HV Amsterdam, The Netherlands
  2.Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, Guangzhou 510030, China
  3.Savaid Stomatology School, Hangzhou Medical College, Hangzhou 310053, China
  4.Department of Plastic Surgery, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China
  5.Hangzhou Huibo Science and Technology Co. LTD, Hangzhou 311217, China
  6.Department of Oral Biochemistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), 1081LA Amsterdam, The Netherlands
  7.Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Gustav Mahlerlaan 3004, 1081LA Amsterdam, The Netherlands
- Author bio：
  
  * chengbiaocheng@163.com;
  g.wu@acta.nl
- Funds：
- DOI：10.1186/s40779-022-00398-9
  CLC：
- Published：2023-08
- Accepted：
Scan QR Code
Lei XX, Cheng LHH, Lin HY, Yang Y, Lu YY, Pang MR, et al. Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing. Mil Med Res. 2022;9(1):41.
DOI：

Lei XX, Cheng LHH, Lin HY, Yang Y, Lu YY, Pang MR, et al. Minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing. Mil Med Res. 2022;9(1):41. DOI： 10.1186/s40779-022-00398-9.

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Oppenheim FG , Xu T , McMillian FM , Levitz SM , Diamond RD , Offner GD , et al . Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans . J Biol Chem . 1988 ; 263 ( 16 ): 7472 - 7 .

Lei X , Cheng L , Lin H , Pang M , Yao Z , Chen C , et al . Human salivary histatin-1 is more efficacious in promoting acute skin wound healing than acellular dermal matrix paste . Front Bioeng Biotechnol . 2020 ; 8 : 999 .

Bray BL . Large-scale manufacture of peptide therapeutics by chemical synthesis . Nat Rev Drug Discov . 2003 ; 2 ( 7 ): 587 - 93 .

Oudhoff MJ , Kroeze KL , Nazmi K , van den Keijbus PAM , Van ‘t Hof W , Fernandez-Borja M , et al . Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold . FASEB J . 2009 ; 23 ( 11 ): 3928 - 35 .

Boink MA , Roffel S , Nazmi K , van Montfrans C , Bolscher JGM , Gefen A , et al . The influence of chronic wound extracts on inflammatory cytokine and histatin stability . PLoS ONE . 2016 ; 11 ( 3 ): e0152613 .

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