Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3

Qin Zhang; Fang-Xing Yu; Yang-Lin Wu; Cheng-Yuan Yang; Nai-Cheng Liu; Xu Zhu; Pi-Ming Zhao; Zhong-Ya Wang; Jun Lin

doi:10.1186/s40779-022-00393-0

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Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3

LETTER TO THE EDITOR | Updated：2023-07-21

- Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
- Military Medical Research Vol. 10, Issue 3, Pages: 418-420(2023)
- Affiliations：
  
  1.Department of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215001, Jiangsu, China
  2.Department of Orthopaedics, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, Jiangsu, China
  3.Department of Gene Therapy, CureGenetics Co., Ltd., Suzhou 215021, Jiangsu, China
- Author bio：
  
  * linjun@suda.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00393-0
  CLC：
- Published：2023-06
- Accepted：
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Cite this article as: Zhang Q, Yu FX, Wu YL, Yang CY, Liu NC, Zhu X, et al. Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3. Mil Med Res. 2022;9(1):34.
DOI：

Cite this article as: Zhang Q, Yu FX, Wu YL, Yang CY, Liu NC, Zhu X, et al. Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3. Mil Med Res. 2022;9(1):34. DOI： 10.1186/s40779-022-00393-0.

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Vande Walle L , van Opdenbosch N , Jacques P , Fossoul A , Verheugen E , Vogel P , et al . Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis . Nature . 2014 ; 512 ( 7512 ): 69 - 73 .

Matmati M , Jacques P , Maelfait J , Verheugen E , Kool M , Sze M , et al . A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis . Nat Genet . 2011 ; 43 ( 9 ): 908 - 12 .

Polykratis A , Martens A , Eren RO , Shirasaki Y , Yamagishi M , Yamaguchi Y , et al . A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain . Nat Cell Biol . 2019 ; 21 ( 6 ): 731 - 42 .

Duong BH , Onizawa M , Oses-Prieto JA , Advincula R , Burlingame A , Malynn BA , et al . A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity . Immunity . 2015 ; 42 ( 1 ): 55 - 67 .

Kang WS , Kwon JS , Kim HB , Jeong HY , Kang HJ , Jeong MH , et al . A macrophage-specific synthetic promoter for therapeutic application of adiponectin . Gene Ther . 2014 ; 21 ( 4 ): 353 - 62 .

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