Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences

Lei Pang; Xi Jiang; Xin Lian; Jie Chen; Er-Fei Song; Lei-Gang Jin; Zheng-Yuan Xia; Hai-Chun Ma; Yin Cai

doi:10.1186/s40779-022-00389-w

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Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences

REVIEW | Updated：2023-03-23

- Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences
- Military Medical Research Vol. 10, Issue 1, Pages: 113-133(2023)
- Affiliations：
  
  1.Department of Anesthesiology, the First Hospital of Jilin University, Changchun 130021 , China
  2.Health Promotion Center, the First Hospital of Jilin University, Changchun 130021 , China
  3.Department of Urology, the First Hospital of Jilin University, Changchun 130021 , China
  4.Henry Fok School of Biology and Agriculture, Shaoguan University, Shaoguan 512000 , Guangdong, China
  5.Department of Metabolic and Bariatric Surgery, Jinan University First Affiliated Hospital, Guangzhou 510630 , China
  6.Department of Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong , China
  7.State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong , China
  8.Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000 , Guangdong, China
  9.Department of Health Technology and Informatics, the Hong Kong Polytechnic University, Hong Kong , China
- Author bio：
  
  * mahc@jlu.edu.cn;
  david-yin.cai@polyu.edu.hk
- Funds：
- DOI：10.1186/s40779-022-00389-w
  CLC：
- Published：2023-02
- Accepted：
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Pang L, Jiang X, Lian X, Chen J, Song EF, Jin LG, et al. Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences. Mil Med Res. 2022;9(1):33.
DOI：

Pang L, Jiang X, Lian X, Chen J, Song EF, Jin LG, et al. Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences. Mil Med Res. 2022;9(1):33. DOI： 10.1186/s40779-022-00389-w.

摘要

Abstract

The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However

do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy

along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in men than women. Furthermore

the patterns of heart failure differ between sexes

as do the lifetime risk factors. Do caloric restriction (CR)-mimetics

rich in polyphenol or polyamine

delay or reverse cardiac aging equally in both men and women? This review will discuss three areas: (1) mechanisms underlying age-related cardiac remodeling; (2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women; (3) we select a few polyphenol or polyamine rich compounds as the CR-mimetics

such as resveratrol

quercetin

curcumin

epigallocatechin gallate and spermidine

due to their capability to extend health-span and induce autophagy. We outline their abilities and issues on retarding aging in animal hearts and preventing CVD in humans. We discuss the confounding factors that should be considered for developing therapeutic strategies against cardiac aging in humans.

关键词

Keywords

references

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