Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

Qing-Long Guo; Xing-Liang Dai; Meng-Yuan Yin; Hong-Wei Cheng; Hai-Sheng Qian; Hua Wang; Dao-Ming Zhu; Xian-Wen Wang

doi:10.1186/s40779-022-00386-z

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Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

REVIEW | Updated：2023-03-23

- Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives
- Military Medical Research Vol. 10, Issue 1, Pages: 94-112(2023)
- Affiliations：
  
  1.School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032 , China
  2.Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230032 , China
  3.Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032 , China
  4.Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, the First School of Clinical Medicine, Southern Medical University, Guangzhou 510515 , China
- Author bio：
  
  * hongwei.cheng@ahmu.edu.cn;
  zhudaoming666@smu.edu.cn;
  xianwenwang@ahmu.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00386-z
  CLC：
- Published：2023-02
- Accepted：
Scan QR Code
Guo QL, Dai XL, Yin MY, Cheng HW, Qian HS, Wang H, et al. Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives. Mil Med Res. 2022;9(1):26.
DOI：

Guo QL, Dai XL, Yin MY, Cheng HW, Qian HS, Wang H, et al. Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives. Mil Med Res. 2022;9(1):26. DOI： 10.1186/s40779-022-00386-z.

摘要

Abstract

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor

and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutation

as well as the presence of the blood–brain barrier (BBB)

have reduced the efficacy of GBM treatment. The emergence of a novel therapeutic method

namely

sonodynamic therapy (SDT)

provides a promising strategy for eradicating tumors

via

activated sonosensitizers coupled with low-intensity ultrasound. SDT can provide tumor killing effects for deep-seated tumors

such as brain tumors. However

conventional sonosensitizers cannot effectively reach the tumor region and kill additional tumor cells

especially brain tumor cells. Efforts should be made to develop a method to help therapeutic agents pass through the BBB and accumulate in brain tumors. With the development of novel multifunctional nanosensitizers and newly emerging combination strategies

the killing ability and selectivity of SDT have greatly improved and are accompanied with fewer side effects. In this review

we systematically summarize the findings of previous studies on SDT for GBM

with a focus on recent developments and promising directions for future research.

关键词

Keywords

references

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