Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

Yun-Juan Nie; Shuo-Hua Wu; Ying-Hua Xuan; Gen Yan

doi:10.1186/s40779-022-00382-3

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Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

REVIEW | Updated：2023-02-28

- Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
- Military Medical Research Vol. 9, Issue 5, Pages: 618-627(2022)
- Affiliations：
  
  1.Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, Jiangsu, China
  2.Department of Radiology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou 515000, Guangdong, China
  3.Department of Basic Medicine, Xiamen Medical College, Xiamen 361000, Fujian, China
  4.Department of Radiology, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361000, Fujian, China
- Author bio：
  
  * gyan@stu.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00382-3
  CLC：
- Published：2022-10
- Accepted：
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Nie YJ, Wu SH, Xuan YH, Yan G. Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis. Mil Med Res. 2022;9(1):21.
DOI：

Nie YJ, Wu SH, Xuan YH, Yan G. Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis. Mil Med Res. 2022;9(1):21. DOI： 10.1186/s40779-022-00382-3.

摘要

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17 (IL-17) isoforms are essential for the mediation of acute and chronic inflammation

via

innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes

including the initiation and exacerbation of IPF. Here

we aim to provide an overview of IL-17 family members in the pathogenesis of IPF.

关键词

Keywords

references

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