Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer

Jing Zhang; Zi-Qin Han; Yang Wang; Qing-Yu He

doi:10.1186/s40779-022-00367-2

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Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer

LETTER TO THE EDITOR | Updated：2023-02-28

- Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer
- Military Medical Research Vol. 9, Issue 5, Pages: 637-638(2022)
- Affiliations：
  
  1.Department of Radiology, the First Affiliated Hospital of Jinan University, Guangzhou 510627, China
  2.MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
  3.MOE Key Laboratory of Tumor Molecular Biology, the First Affiliated Hospital of Jinan University, Guangzhou 510627, China
- Author bio：
  
  * wangyang8857@gmail.com;
  tqyhe@email.jnu.edu.cn
- Funds：
- DOI：10.1186/s40779-022-00367-2
  CLC：
- Published：2022-10
- Accepted：
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Zhang J, Han ZQ, Wang Y, He QY. Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer. Mil Med Res. 2022;9(1):6.
DOI：

Zhang J, Han ZQ, Wang Y, He QY. Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer. Mil Med Res. 2022;9(1):6. DOI： 10.1186/s40779-022-00367-2.

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references

Wang Y , Zhang J , Li B , He QY . Advances of proteomics in novel PTM discovery: applications in cancer therapy . Small Methods . 2019 ; 3 ( 5 ): 1900041 .

Wang YG , Guo YR , Liu K , Yin Z , Liu R , Xia Y . KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase . Nature . 2017 ; 552 ( 7684 ): 273 - 7 .

Gut P , Matilainen S , Meyer JG , Pallijeff P , Richard J , Carroll CJ , et al . SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease . Nat Commun . 2020 ; 11 ( 1 ): 5927 .

Tong Y , Guo D , Lin SH , Liang J , Yang D , Ma C , et al . SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells . Mol Cell . 2021 ; 81 ( 11 ): 2303-16.e8 .

Gregory MA , Nemkov T , Park HJ , Zaberezhnyy V , Gehrke S , Adane B , et al . Targeting glutamine metabolism and redox state for leukemia therapy . Clin Cancer Res . 2019 ; 25 ( 13 ): 4079 - 90 .

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