Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?

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Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?

REVIEW | Updated：2023-02-28

- Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
- Military Medical Research Vol. 9, Issue 5, Pages: 592-602(2022)
- Affiliations：
  
  1.Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
  2.Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
- Author bio：
  
  * hzlgy496@hotmail.com
- Funds：
- DOI：10.1186/s40779-021-00362-z
  CLC：
- Published：2022-10
- Accepted：
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Shen Z, Tang CM, Liu GY. Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?. Mil Med Res. 2022;9(1):3.
DOI：

Shen Z, Tang CM, Liu GY. Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?. Mil Med Res. 2022;9(1):3. DOI： 10.1186/s40779-021-00362-z.

摘要

Abstract

Bacteria can evolve rapidly by acquiring new traits such as virulence

metabolic properties

and most importantly

antimicrobial resistance

through horizontal gene transfer (HGT). Multidrug resistance in bacteria

especially in Gram-negative organisms

has become a global public health threat often through the spread of mobile genetic elements. Conjugation represents a major form of HGT and involves the transfer of DNA from a donor bacterium to a recipient by direct contact. Conjugative plasmids

a major vehicle for the dissemination of antimicrobial resistance

are selfish elements capable of mediating their own transmission through conjugation. To spread to and survive in a new bacterial host

conjugative plasmids have evolved mechanisms to circumvent both host defense systems and compete with co-resident plasmids. Such mechanisms have mostly been studied in model plasmids such as the F plasmid

rather than in conjugative plasmids that confer antimicrobial resistance (AMR) in important human pathogens. A better understanding of these mechanisms is crucial for predicting the flow of antimicrobial resistance-conferring conjugative plasmids among bacterial populations and guiding the rational design of strategies to halt the spread of antimicrobial resistance. Here

we review mechanisms employed by conjugative plasmids that promote their transmission and establishment in Gram-negative bacteria

by following the life cycle of conjugative plasmids.

关键词

Keywords

references

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