The roles of exosomal immune checkpoint proteins in tumors

Cheng Xing; Heng Li; Rui-Juan Li; Le Yin; Hui-Fang Zhang; Zi-Neng Huang; Zhao Cheng; Ji Li; Zhi-Hua Wang; Hong-Ling Peng

doi:10.1186/s40779-021-00350-3

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The roles of exosomal immune checkpoint proteins in tumors

REVIEW | Updated：2023-02-28

- The roles of exosomal immune checkpoint proteins in tumors
- Military Medical Research Vol. 9, Issue 3, Pages: 365-375(2022)
- Affiliations：
- Author bio：
  
  * wangzhihuazsc@csu.edu.cn;
  penghongling@csu.edu.cn
- Funds：
- DOI：10.1186/s40779-021-00350-3
  CLC：
- Published：2022-06
- Accepted：
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Xing et al.: The roles of exosomal immune checkpoint proteins in tumors. Mil Med Res, 2021, 8: 56.
DOI：

Xing et al.: The roles of exosomal immune checkpoint proteins in tumors. Mil Med Res, 2021, 8: 56. DOI： 10.1186/s40779-021-00350-3.

摘要

Abstract

Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However

most patients develop adaptive resistance to this therapy. The latest evidence demonstrates that tumor-derived exosomes may play a key role in systemic immune suppression and tumor progression. In this article

we highlight the role of exosomal immune checkpoint proteins in tumor immunity

with an emphasis on programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

as well as emerging evidence on roles of T cell immunoglobulin-3 (TIM-3)

arginase 1 (ARG1)

and estrogen receptor binding fragment-associated antigen 9 (EBAG9) expressed by exosomes.

关键词

Keywords

references

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