Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling

Xi-Yao Chen; Yang Jiao; Fu-Yang Zhang

doi:10.1186/s40779-021-00347-y

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Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling

LETTER TO THE EDITOR | Updated：2023-02-28

- Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling
- Military Medical Research Vol. 9, Issue 3, Pages: 382-384(2022)
- Affiliations：
  
  1.Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  2.Department of Stomatology, the 7th Medical Center of Chinese, PLA General Hospital, Beijing 100700, China
  3.Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
- Author bio：
  
  * plazhangfuyang@163.com
- Funds：
- DOI：10.1186/s40779-021-00347-y
  CLC：
- Published：2022-06
- Accepted：
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Chen et al.: Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling. Mil Med Res, 2021, 8: 53.
DOI：

Chen et al.: Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling. Mil Med Res, 2021, 8: 53. DOI： 10.1186/s40779-021-00347-y.

摘要

Abstract

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling

emphasizing the therapeutic potential of PPARα activation strategies (e.g.

fenofibrate treatment) in LT-associated cardiac injury.

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Keywords

references

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