Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

Shuai Yuan; Cheng Fang; Wei-Dong Leng; Lan Wu; Bing-Hui Li; Xing-Huan Wang; Hailiang Hu; Xian-Tao Zeng

doi:10.1186/s40779-021-00344-1

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Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

REVIEW | Updated：2023-02-28

- Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers
- Military Medical Research Vol. 8, Issue 4, Pages: 564-578(2021)
- Affiliations：
  
  1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
  3.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  4.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  5.Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA
  6.School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
- Author bio：
  
  * wangxinghuan1695@163.com;
  huhl@sustech.edu.cn;
  zengxiantao1128@whu.edu.cn; zengxiantao1128@163.com
- Funds：
- DOI：10.1186/s40779-021-00344-1
  CLC：
- Published：2021-12
- Accepted：
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Yuan et al.: Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res, 2021, 8: 54.
DOI：

Yuan et al.: Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res, 2021, 8: 54. DOI： 10.1186/s40779-021-00344-1.

摘要

Abstract

Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although periodontitis and genitourinary cancers are two totally distinct types of disorders

epidemiological and clinical studies

have established associations between them. Dysbiosis of oral microbiota has already been established as a major factor contributing to periodontitis. Recent emerging epidemiological evidence and the detection of oral microbiota in genitourinary organs indicate the presence of an oral-genitourinary axis and oral microbiota may be involved in the pathogenesis of genitourinary cancers. Therefore

oral microbiota provides the bridge between periodontitis and genitourinary cancers. We have carried out this narrative review which summarizes epidemiological studies exploring the association between periodontitis and genitourinary cancers. We have also highlighted the current evidence demonstrating the capacity of oral microbiota to regulate almost all hallmarks of cancer

and proposed the potential mechanisms of oral microbiota in the development of genitourinary cancers.

关键词

Keywords

references

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Yun-Yun Wang

Di Huang

Cong Zhu

Cheng Fang

Related Institution

Research Center for Medical Device Regulatory Science, Lanzhou University

Department of Stomatology, Daping Hospital, Army Medical University

Henan Provincial Engineering Research Center for Microecological Regulatory of Oral Environment and Oral Implantology, Kaifeng University Health Science Center

Center for Evidence-Based and Trans-lational Medicine, Zhongnan Hospital of Wuhan University

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University

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