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Antimicrobial peptides: mechanism of action, activity and clinical potential
- Military Medical Research Vol. 9, Issue 2, Pages: 231-258(2022)
- Affiliations：
1.Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928, Street 2, Xiasha Higher Education Zone, Hangzhou 310018, China
2.Department of Oncology, The 903rd Hospital of PLA, Hangzhou 310013, China
3.Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Blvd. South, San Francisco, CA 94158, USA
4.Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia
5.Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia
- Author bio：
* fucy03@zstu.edu.cn
- Funds：
DOI：10.1186/s40779-021-00343-2
CLC：-
Published：2022-04
- Accepted：
Scan QR Code
Zhang et al.: Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res, 2021, 8: 48.
Zhang et al.: Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res, 2021, 8: 48. DOI： 10.1186/s40779-021-00343-2.
摘要
Abstract
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance
antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin
structural characteristics
mechanisms of action
biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
关键词
Keywords
references
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