Research progress in the effects of terahertz waves on biomacromolecules

Liu Sun; Li Zhao; Rui-Yun Peng

doi:10.1186/s40779-021-00321-8

Your Location：

Home >

Browse articles >

Research progress in the effects of terahertz waves on biomacromolecules

REVIEW | Updated：2023-02-28

- Research progress in the effects of terahertz waves on biomacromolecules
- Military Medical Research Vol. 9, Issue 1, Pages: 63-70(2022)
- Affiliations：
  
  Beijing Institute of Radiation Medicine, Haidian District, 27 Taiping Road, Beijing 100850, China
- Author bio：
  
  * lillyliz@163.com;
  ruiyunpeng18@126.com
- Funds：
- DOI：10.1186/s40779-021-00321-8
  CLC：
- Published：2022-02
- Accepted：
Scan QR Code
Sun et al.: Research progress in the effects of terahertz waves on biomacromolecules. Mil Med Res, 2021, 8: 28.
DOI：

Sun et al.: Research progress in the effects of terahertz waves on biomacromolecules. Mil Med Res, 2021, 8: 28. DOI： 10.1186/s40779-021-00321-8.

摘要

Abstract

With the rapid development of terahertz technologies

basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomacromolecules fall in the energy range of terahertz waves; thus

terahertz waves might interact with biomacromolecules. Therefore

terahertz waves have been widely applied to explore features of the terahertz spectrum of biomacromolecules. However

the effects of terahertz waves on biomacromolecules are largely unexplored. Although some progress has been reported

there are still numerous technical barriers to clarifying the relation between terahertz waves and biomacromolecules and to realizing the accurate regulation of biological macromolecules by terahertz waves. Therefore

further investigations should be conducted in the future. In this paper

we reviewed terahertz waves and their biomedical research advantages

applications of terahertz waves on biomacromolecules and the effects of terahertz waves on biomacromolecules. These findings will provide novel ideas and methods for the research and application of terahertz waves in the biomedical field.

关键词

Keywords

references

Yang H . Preliminary study of biological organization by terahertz time-domain spectroscopy . Nanjing : Nanjing Med Univ ; 2013 .

Yan H . Experimental and theoretical study of terahertz spectra of organic molecules . Beijing : Grad Sch Chin Acad Sci ; 2012 .

He MX , Chen T . Application of terahertz science and technology in biomedicine . J Electron Meas Instrum . 2012 ; 26 ( 6 ): 471 - 83 . https://doi.org/10.3724/SP.J.1187.2012.00471 https://doi.org/10.3724/SP.J.1187.2012.00471 .

Fu WL , Huang Q . New field of laboratory medicine in the 21st century: terahertz-inspective medicine . Chin J Lab Med . 2015 ; 38 ( 1 ): 1 - 3 . https://doi.org/10.3760/cma.j.issn.1009-9158.2015.01.001 https://doi.org/10.3760/cma.j.issn.1009-9158.2015.01.001 .

Zhou J , Liu SG . Research progress in terahertz biomedical applications . Mod Appl Phys . 2014 ; 5 ( 2 ): 85 - 97 . https://doi.org/10.3969/j.issn.2095-6223.2014.02.001 https://doi.org/10.3969/j.issn.2095-6223.2014.02.001 .

Wu HH . Optical terahertz radiation generation technology . Beijing : Grad Sch Chin Acad Sci ; 2012 .

Zhang Y . Research on biological tissue lesion detection method based on terahertz time domain spectroscopy . Hangzhou : Zhejiang Univ ; 2018 .

Liang PL , Dai JM . A review of terahertz science and technology . Tech Auto Appl . 2015 ; 34 ( 6 ): 1 - 8 .

Wahaia F , Valusis G , Bernardo LM , Almeida A , Moreira JA , Lopes PC , et al . Detection of colon cancer by terahertz techniques . J Mol Struct . 2011 ; 1006 ( 1 ): 77 - 82 . https://doi.org/10.1016/j.molstruc.2011.05.049 https://doi.org/10.1016/j.molstruc.2011.05.049 .

Ebbinghaus S , Kim SJ , Heyden M , Yu X , Heugen U , Gruebele M , et al . An extended dynamical hydration shell around proteins . Proc Natl Acad Sci U S A . 2007 ; 104 ( 52 ): 20749 - 52 . https://doi.org/10.1073/pnas.0709207104 https://doi.org/10.1073/pnas.0709207104 .

Cao C . Protein molecules conformation recognition and their interactions characterization based on terahertz spectroscopy . Beijing : USTB ; 2021 .

Wang YF , Wei WC , Zhou FJ , Xue ZH . Application of terahertz spectroscopy in the study of biomacromolecules . Prog Biochem Biophys . 2010 ; 37 ( 5 ): 484 - 9 . https://doi.org/10.3724/SP.J.1206.2009.00562 https://doi.org/10.3724/SP.J.1206.2009.00562 .

Tang ZF , Lin HT , Chen XW , Zhang ZF . Amino acid detection based on terahertz spectroscopy . Spectrosc Spect Anal . 2009 ; 29 ( 9 ): 2351 - 6 . https://doi.org/10.3964/j.issn.1000-0593(2009)09-2351-06 https://doi.org/10.3964/j.issn.1000-0593(2009)09-2351-06 .

Xie MZ , Jiang LY , Che TJ , He JC . Application of terahertz technology in detecting protein organic compounds . J Lanzhou Univ . 2018 ; 44 ( 6 ): 70 - 5 . https://doi.org/10.13885/j.issn.1000-2812.2018.06.013 https://doi.org/10.13885/j.issn.1000-2812.2018.06.013 .

Ma XJ , Zhao HW , Dai B , Ge M . Progress in the application of terahertz time-domain spectroscopy in protein research . Spectrosc Spect Anal . 2008 ; 28 ( 10 ): 2237 - 42 . https://doi.org/10.3964/j.issn.1000-0593(2008)10-2237-06 https://doi.org/10.3964/j.issn.1000-0593(2008)10-2237-06 .

Wang WN , Yue WW , Yan HT , Zhang CL , Zhao GZ . Terahertz time-domain spectroscopy of amino acid molecules . Sci Bull . 2005 ; 50 ( 21 ): 2348 - 51 . https://doi.org/10.3321/j.issn:0023-074X.2005.21.003 https://doi.org/10.3321/j.issn:0023-074X.2005.21.003 .

Yue WW , Wang WN , Zhao GZ , Zhang CL , Yan HT . Terahertz spectroscopy of aromatic amino acids . Acta Phys Sin . 2005 ; 7 : 3094 - 9 . https://doi.org/10.3321/j.issn:1000-3290.2005.07.022 https://doi.org/10.3321/j.issn:1000-3290.2005.07.022 .

Hui X , Yu XH , Zhang ZY , Han JG , Li JY , Zhu QY , et al . THz time-domain spectroscopy of solid amino acids . J Grad Sch Chin Acad Sci . 2005 ; 22 ( 1 ): 90 - 3 . https://doi.org/10.3969/j.issn.1002-1175.2005.01.014 https://doi.org/10.3969/j.issn.1002-1175.2005.01.014 .

Wang WN , Li YB , Yue WW . Terahertz spectroscopy of histidine and arginine . Acta Phys Sin . 2007 ; 56 ( 2 ): 781 - 5 . https://doi.org/10.3321/j.issn:1000-3290.2007.02.028 https://doi.org/10.3321/j.issn:1000-3290.2007.02.028 .

Ma SH , Shi YL , Xu XL , Yan W , Yang YP , Wang L . Detecting the low-frequency collective absorption spectrum of asparagine by terahertz timedomain spectroscopy . Acta Phys Sin . 2006 ; 8 : 4091 - 5 . https://doi.org/10.3321/j.issn:1000-3290.2006.08.051 https://doi.org/10.3321/j.issn:1000-3290.2006.08.051 .

Song GA . The functional role and development prospect of nucleic acids . Grain Storage . 2003 . http://www.cnki.com.cn/Article/CJFDTOTAL-SCEL200304023.htm http://www.cnki.com.cn/Article/CJFDTOTAL-SCEL200304023.htm . Accessed 29 Apr 2020 .

Li ML . Biomolecular identification and interaction based on terahertz time-domain spectroscopy . Jilin : Jilin Univ ; 2018 .

Xu H , Li WX . Interaction between terahertz radiation and biomolecules . Nucl Technol . 2004 ; 27 ( 7 ): 534 - 40 . https://doi.org/10.3321/j.issn:0253-3219.2004.07.013 https://doi.org/10.3321/j.issn:0253-3219.2004.07.013 .

Li YC . Application of terahertz spectroscopy in nucleic acid detection . Chongqing : The Third Mil Med Univ ; 2016 .

Sun Q , He Y , Liu K , Fan S , Parrott Edward PJ , Pickwell E . Recent advances in terahertz technology for biomedical applications . Quant Imaging Med Surg . 2017 ; 7 ( 3 ): 345 - 55 . https://doi.org/10.21037/qims.2017.06.02 https://doi.org/10.21037/qims.2017.06.02 .

Cheon H , Yang HJ , Lee SH , Kim YA , Son JH . Terahertz molecular resonance of cancer DNA . Sci Rep . 2016 ; 6 ( 1 ): 37103 . https://doi.org/10.1038/srep37103 https://doi.org/10.1038/srep37103 .

Ma X , Zhao HW , Liu GF , Ji T , Zhang ZY , Dai B . Qualitative and quantitative analyses of some saccharides by terahertz time-domain spectroscopy . Spectrosc Spectr Anal . 2009 ; 29 ( 11 ): 2885 - 8 . https://doi.org/10.3964/j.issn.1000-0593(2009)11-2885-04 https://doi.org/10.3964/j.issn.1000-0593(2009)11-2885-04 .

Chen T , Cai ZH , Hu FR , Yin XH , Xu CP . Terahertz time-domain spectroscopy study of structurally similar monosaccharide and disaccharide molecules . Spectrosc Spect Anal . 2019 ; 39 ( 3 ): 686 - 92 . https://doi.org/10.3964/j.issn.1000-0593(2019)03-0686-07 https://doi.org/10.3964/j.issn.1000-0593(2019)03-0686-07 .

Cai TX , Liu PS , Yang FQ , Yang FY . Progress in lipid omics . Prog Biochem Biophys . 2010 ; 37 ( 2 ): 121 - 8 . https://doi.org/10.3724/SP.J.1206.2009.00479 https://doi.org/10.3724/SP.J.1206.2009.00479 .

Zhang WF . Research on terahertz detection of vascular plaques . Shenyang : Northeastern Univ ; 2009 .

Chen T . Terahertz spectra of different cancerous tissues and their comparative studies . Tianjin : Tianjin Univ ; 2012 .

Yan FY . Terahertz spectroscopy study on the cancerous characteristics of skin tissue . Tianjin : Tianjin Univ ; 2012 .

Kang L , Yan Q , Hu YS , Yin HY , Yu SG , Zhou X . Terahertz technology and application of traditional Chinese medicine . WJTCM . 2020 ; 15 ( 11 ): 1546 - 50 . https://doi.org/10.3969/j.issn.1673-7202.2020.11.006 https://doi.org/10.3969/j.issn.1673-7202.2020.11.006 .

Zhang ZN , Li SC , Qiu LZ , Zhang WC . The application status and prospect of terahertz wave technology in the field of traditional Chinese medicine . Jiangxi Trad Chin Med . 2020 . http://www.cnki.com.cn/Article/CJFDTOTALJXZY202002034. htm http://www.cnki.com.cn/Article/CJFDTOTALJXZY202002034. htm . Accessed 29 Apr 2020 .

Yu ZP , Zhang L . Progress and prospective in biological effects of terahertz radiation . J Third Mil Med Univ . 2020 ; 42 ( 23 ): 2259 - 66 . https://doi.org/10.16016/j.1000-5404.202008139 https://doi.org/10.16016/j.1000-5404.202008139 .

Xie PF , Liu XD , Sun YW . Inspiration for terahertz radiation induced biological effects on cells . Chin J Lasers . 2019 ; 46 ( 6 ): 169 - 79 . https://doi.org/10.3788/CJL201946.0614013 https://doi.org/10.3788/CJL201946.0614013 .

Sun JH . The application principle and progress of terahertz electromagnetic wave in medical field . J Cap Nor Univ . 2004 ; 4 : 17 - 22 . https://doi.org/10.3969/j.issn.1004-9398.2004.04.006 https://doi.org/10.3969/j.issn.1004-9398.2004.04.006 .

Govorun VM , Tretiakov VE , Tulyakov NN , Fleurov VB , Demin AL , Volov AY , et al . Far-infrared radiation effect on the structure and properties of proteins . Int J Infrared Milli . 2005 ; 12 ( 12 ): 1469 - 74 .

Titova LV , Ayesheshim AK , Golubov A , Fogen D , Rodriguez-Juarez R , Hegmann FA , et al . Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue . Biomed Opt Express . 2013 ; 4 ( 4 ): 559 - 68 . https://doi.org/10.1364/BOE.4.000559 https://doi.org/10.1364/BOE.4.000559 .

Homenko A , Kapilevich B , Kornstein R , Firer MA . Effects of 100 GHz radiation on alkaline phosphatase activity and antigen-antibody interaction . Bioelectromagnetics . 2009 ; 30 ( 3 ): 167 - 75 . https://doi.org/10.1002/bem.20466 https://doi.org/10.1002/bem.20466 .

Borovkova M , Serebriakova M , Fedorov V , Sedykh E , Vaks V , Lichutin A , et al . Investigation of terahertz radiation influence on rat glial cells . Biomed Opt Express . 2016 ; 8 ( 1 ): 273 - 80 . https://doi.org/10.1364/BOE.8.000273 https://doi.org/10.1364/BOE.8.000273 .

Demidova EV , Goryachkovskaya TN , Malup TK , Bannikova SV , Semenov AI , Vinokurov NA , et al . Studying the non-thermal effects of terahertz radiation on E. coli/pKatG-GFP biosensor cells . Bioelectromagnetics . 2013 ; 34 ( 1 ): 15 - 21 . https://doi.org/10.1002/bem.21736 https://doi.org/10.1002/bem.21736 .

Chen CH , Ma QL , Tao JW , Lu YH , Lin M , Gao P , et al . Study on the effect of terahertz radiation exposure on skin injury in mice . J Third Mil Med Univ . 2020 ; 42 ( 23 ): 2282 - 9 . https://doi.org/10.16016/j.1000-5404.202008138 https://doi.org/10.16016/j.1000-5404.202008138 .

Tan SZ , Tan PC , Luo LQ , Chi YL , Yang ZL , Zhao XL , et al . Exposure effects of terahertz waves on primary neurons and neuron-like cells under nonthermal conditions . Biomed Environ Sci . 2019 ; 32 ( 10 ): 739 - 54 . https://doi.org/10.3967/bes2019.094 https://doi.org/10.3967/bes2019.094 .

De Amicis A , Sanctis SD , Cristofaro SD , Franchini V , Lista F , Regalbuto E , et al . Biological effects of in vitro THz radiation exposure in human foetal fibroblasts . Mutat Res Genet Toxicol Environ Mutagen . 2015 ; 793 : 150 - 60 . https://doi.org/10.1016/j.mrgentox.2015.06.003 https://doi.org/10.1016/j.mrgentox.2015.06.003 .

Williams R , Schofield A , Holder G , Downes J , Edgar D , Harrison P , et al . The influence of high intensity terahertz radiation on mammalian cell adhesion, proliferation and differentiation . Phys Med Biol . 2013 ; 58 ( 2 ): 373 - 91 . https://doi.org/10.1016/j.mrgentox.2015.06.003 https://doi.org/10.1016/j.mrgentox.2015.06.003 .

Koyama S , Narita E , Shimizu Y , Shiina T , Taki M , Shinohara N , et al . Twenty four-hour exposure to a 0.12 THz electromagnetic field does not affect the genotoxicity, morphological changes, or expression of heat shock protein in HCE-T cells . Int J Environ Res Public Health . 2016 ; 13 ( 8 ): 793 .

Alexandrov BS , Gelev V , Bishop AR , Usheva A , Rasmussen KO . DNA breathing dynamics in the presence of a terahertz field . Phys Lett A . 2010 ; 374 ( 10 ): 1214 - 7 . https://doi.org/10.1016/j.physleta.2009.12.077 https://doi.org/10.1016/j.physleta.2009.12.077 .

Hintzsche H , Jastrow C , Kleine-Ostmann T , Kärst U , Schrader T , Stopper H . Terahertz electromagnetic fields (0.106 THz) do not induce manifest genomic damage in vitro . PLoS One . 2012 ; 7 ( 9 ): e46397 .

Berns MW , Bewley W , Sun CH , Templin P . Free electron laser irradiation at 200 microns affects DNA synthesis in living cells . Proc Natl Acad Sci U S A . 1990 ; 87 ( 7 ): 2810 - 2 . https://doi.org/10.1073/pnas.87.7.2810 https://doi.org/10.1073/pnas.87.7.2810 .

Cheon H , Paik JH , Choi M , Yang HJ , Son JH . Detection and manipulation of methylation in blood cancer DNA using terahertz radiation . Sci Rep . 2019 ; 9 ( 1 ): 6413 . https://doi.org/10.1038/s41598-019-42855-x https://doi.org/10.1038/s41598-019-42855-x .

Ma QL , Chen CH , Lin M , Tao JW , Deng P , Gao P , et al . Non-thermal effects of 0.22 terahertz electromagnetic radiation exposure-induced injury in Neuro-2a cells . J Third Mil Med Univ . 2020 ; 42 ( 23 ): 2267-73+89 . https://doi.org/10.16016/j.1000-5404.202008145 https://doi.org/10.16016/j.1000-5404.202008145 .

Lu YH , Chen CH , Gao P , Ma QL , He MD , Zhang L , et al . Terahertz radiation exposure results in altered gene expression profile in mouse retina . J Third Mil Med Univ . 2020 ; 42 ( 23 ): 2274 - 81 . https://doi.org/10.16016/j.1000-5404.202008140 https://doi.org/10.16016/j.1000-5404.202008140 .

Wei C , Zhang Y , Li R , Wang S , Wang T , Liu J , et al . Terahertz irradiation induced motility enhancement and intracellular calcium elevation in human sperm in vitro . Biomed Opt Express . 2018 ; 9 ( 9 ): 3998 - 4008 . https://doi.org/10.1364/BOE.9.003998 https://doi.org/10.1364/BOE.9.003998 .

Wilmink GJ , Rivest BD , Roth CC , Ibey BL , Payne JA , Cundin LX , et al . In vitro investigation of the biological effects associated with human dermal fibroblasts exposed to 2.52 THz radiation . Lasers Surg Med . 2011 ; 43 ( 2 ): 152 - 63 . https://doi.org/10.1002/lsm.20960 https://doi.org/10.1002/lsm.20960 .

Zeni O , Gallerano GP , Perrotta A , Romanò M , Sannino A , Sarti M , et al . Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study . Health Phys . 2007 ; 92 ( 4 ): 349 - 57 . https://doi.org/10.1097/01.HP.0000251248.23991.35 https://doi.org/10.1097/01.HP.0000251248.23991.35 .

Alexandrov BS , Phipps ML , Alexandrov LB , Booshehri LG , Erat A , Zabolotny J , et al . Specificity and heterogeneity of terahertz radiation effect on gene expression in mouse mesenchymal stem cells . Sci Rep . 2013 ; 3 ( 1 ): 1184 . https://doi.org/10.1038/srep01184 https://doi.org/10.1038/srep01184 .

Zhao JW , He MX , Dong LJ , Li SX , Liu LY , Bu SC , et al . Effect of terahertz pulse on gene expression in human eye cells . Chin Phys B . 2019 ; 28 ( 4 ): 405 - 11 . https://doi.org/10.1088/1674-1056/28/4/048703 https://doi.org/10.1088/1674-1056/28/4/048703 .

Titova LV , Ayesheshim AK , Golubov A , Rodriguez-Juarez R , Woycicki R , Hegmann FA , et al . Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? Sci Rep . 2013 ; 3 ( 1 ): 2363 . https://doi.org/10.1038/srep02363 https://doi.org/10.1038/srep02363 .

Bock J , Fukuyo Y , Kang S , Phipps ML , Alexandrov LB , Rasmussen KØ , et al . Mammalian stem cells reprogramming in response to terahertz radiation . PLoS One . 2010 ; 5 ( 12 ): e15806 . https://doi.org/10.1371/journal.pone.0015806 https://doi.org/10.1371/journal.pone.0015806 .

Bogomazova AN , Vassina EM , Goryachkovskaya TN , Popik VM , Sokolov AS , Kolchanov NA , et al . No DNA damage response and negligible genomewide transcriptional changes in human embryonic stem cells exposed to terahertz radiation . Sci Rep . 2015 ; 5 ( 1 ): 7749 . https://doi.org/10.1038/srep07749 https://doi.org/10.1038/srep07749 .

Ramundo OA , Gallerano GP , Stano P , Doria A , Giovenale E , Messina G , et al . Permeability changes induced by 130 GHz pulsed radiation on cationic liposomes loaded with carbonic anhydrase . Bioelectromagnetics . 2007 ; 28 ( 8 ): 587 - 98 . https://doi.org/10.1002/bem.20343 https://doi.org/10.1002/bem.20343 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Establishment of injury models in studies of biological effects induced by microwave radiation

Research on Synthetical 3 Factors Checking Method for the Ultimate Load Carrying Capacity of Steel Arch Bridges

Digital Demodulation Method for Multi-tone FM Signal in Track Circuit System

Coupling Vibration Analysis on Yuxi River Bridge of Wuhu Yangtze River Bridge

Kalman Dynamic Adaptive Filtering to Railway Line Measurement Signals of Tilting Train

Related Author

Yun-Fei Lai

Hao-Yu Wang

Rui-Yun Peng

Related Institution

Beijing Institute of Radiation Medicine

⁰