Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study

Muhammad R. Baig; Robert D. Beck; Jennifer L. Wilson; Jennifer A. Lemmer; Adeel Meraj; Eric C. Meyer; Jim Mintz; Alan L. Peterson; John D. Roache

doi:10.1186/s40779-020-00278-0

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Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study

STUDY PROTOCOL | Updated：2023-02-28

- Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study
- Military Medical Research Vol. 8, Issue 1, Pages: 121-131(2021)
- Affiliations：
  
  1.Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA
  2.Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, TX, USA
  3.Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
  4.Department of Veterans Affairs VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA
  5.Central Texas Veterans Healthcare System, Waco, TX, USA
  6.Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA
  7.Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
  8.Department of Psychology, University of Texas at San Antonio, San Antonio, USA
  9.Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Author bio：
  
  * Muhammad.baig@va.gov
- Funds：
- DOI：10.1186/s40779-020-00278-0
  CLC：
- Published：2021-03
- Accepted：
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Baig et al.: Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study. Mil Med Res, 2020, 7: 46.
DOI：

Baig et al.: Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study. Mil Med Res, 2020, 7: 46. DOI： 10.1186/s40779-020-00278-0.

摘要

Abstract

Background:

Selective serotonergic reuptake inhibitors (SSRIs) are first-line pharmacologic treatments for patients with posttraumatic stress disorder (PTSD)

but must be given over extended period of time before the onset of action. The use of SSRIs in PTSD patients with mild traumatic brain injury (mTBI) is problematic since SSRIs could exacerbate post-concussion syndrome (PCS) symptoms. VA/DOD guidelines identify trauma-focused psychotherapy as the best evidence-based treatment for PTSD

but overall effectiveness is limited by reduced levels of patient engagement and retention. A previous study from this research group suggested that quetiapine monotherapy

but not risperidone or valproate

could increase engagement in trauma-focused psychotherapy.

Methods:

We report the study protocol of a pilot study funded under the South-Central Mental Illness Research

Education

and Clinical Center pilot study program from the U.S. Department of Veterans Affairs. This randomized

open-label study was designed to evaluate the feasibility of completing a randomized trial of quetiapine

. treatment as usual to promote patient engagement in PTSD patients with a history of mTBI.

Discussion:

We expect that the success of this ongoing study should provide us with the preliminary data necessary to design a full-scale randomized trial. Positive efficacy results in a full-scale trial should inform new VA guidelines for clinical practice by showing that quetiapine-related improvements in patient engagement and retention may be the most effective approach to assure that VA resources achieve the best possible outcome for veterans.

Trial registration:

NCT04280965.

关键词

Keywords

references

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