EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Ji-Hang Zhang; Yang Shen; Chuan Liu; Jie Yang; Yuan-Qi Yang; Chen Zhang; Shi-Zhu Bian; Jie Yu; Xu-Bin Gao; Lai-Ping Zhang; Jing-Bin Ke; Fang-Zheng-Yuan Yuan; Wen-Xu Pan; Zhi-Nian Guo; Lan Huang

doi:10.1186/s40779-020-00264-6

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EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

RESEARCH | Updated：2023-02-28

- EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study
- Military Medical Research Vol. 8, Issue 1, Pages: 25-36(2021)
- Affiliations：
  
  Institute of Cardiovascular Diseases, Department of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China
- Author bio：
  
  * huanglan260@126.com
- Funds：
- DOI：10.1186/s40779-020-00264-6
  CLC：
- Published：2021-03
- Accepted：
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Zhang et al.: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study. Mil Med Res, 2020, 7: 35.
DOI：

Zhang et al.: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study. Mil Med Res, 2020, 7: 35. DOI： 10.1186/s40779-020-00264-6.

摘要

Abstract

Background:

More people ascend to high altitude (HA) for various activities

and some individuals are susceptible to HA illness after rapidly ascending from plains. Acute mountain sickness (AMS) is a general complaint that affects activities of daily living at HA. Although genomic association analyses suggest that single nucleotide polymorphisms (SNPs) are involved in the genesis of AMS

no major gene variants associated with AMS-related symptoms have been identified.

Methods:

In this cross-sectional study

604 young

healthy Chinese Han men were recruited in June and July of 2012 in Chengdu

and rapidly taken to above 3700 m by plane. Basic demographic parameters were collected at sea level

and heart rate

pulse oxygen saturation (SpO

)

systolic and diastolic blood pressure and AMS-related symptoms were determined within 18–24 h after arriving in Lhasa. AMS patients were identified according to the latest Lake Louise scoring system (LLSS). Potential associations between variant genotypes and AMS/AMS-related symptoms were identified by logistic regression after adjusting for potential confounders (age

body mass index and smoking status).

Results:

In total

320 subjects (53.0%) were diagnosed with AMS

with no cases of high-altitude pulmonary edema or high-altitude cerebral edema. SpO

was significantly lower in the AMS group than that in the non-AMS group (

=0.003). Four SNPs in hypoxia-inducible factor-related genes were found to be associated with AMS before multiple hypothesis testing correction. The rs6756667 (EPAS1) was associated with mild gastrointestinal symptoms (

=0.013)

while rs3025039 (VEGFA) was related to mild headache (

=0.0007). The combination of rs6756667 GG and rs3025039 CT/TT further increased the risk of developing AMS (

=2.70

0.001).

Conclusions:

Under the latest LLSS

we find that EPAS1 and VEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population; this tool might be useful for screening susceptible populations and predicting clinical symptoms leading to AMS before an individual reaches HA.

Trial registration:

Chinese Clinical Trial Registration

ChiCTR-RCS-12002232. Registered 31 May 2012.

关键词

Keywords

references

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