Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients

Qi Wang; Hong Zhao; Li-Gai Liu; Yan-Bin Wang; Ting Zhang; Ming-Hui Li; Yan-Li Xu; Gui-Ju Gao; Hao-Feng Xiong; Ying Fan; Ying Cao; Rui Ding; Jing-Jing Wang; Cheng Cheng; Wen Xie

doi:10.1186/s40779-020-00256-6

Your Location：

Home >

Browse articles >

Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients

RESEARCH | Updated：2023-02-28

- Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients
- Military Medical Research Vol. 8, Issue 1, Pages: 9-16(2021)
- Affiliations：
  
  1.Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  2.Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China
  3.Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  4.Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Author bio：
  
  * xiewen6218@163.com
- Funds：
- DOI：10.1186/s40779-020-00256-6
  CLC：
- Published：2021-03
- Accepted：
Scan QR Code
Wang et al.: Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients. Mil Med Res, 2020, 7: 28.
DOI：

Wang et al.: Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients. Mil Med Res, 2020, 7: 28. DOI： 10.1186/s40779-020-00256-6.

摘要

Abstract

Background:

Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However

few data on the combined analysis and change patterns of alanine aminotransferase (ALT)

aspartate aminotransferase (AST) and total bilirubin (TBil) have been shown.

Methods:

This is a single-center retrospective study. A total of 105 adult patients hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12

and March 17

2020 were included

and divided into mild group (

=79) and severe group (

=26). We compared liver functional test results between the two groups. Category of ALT change during the disease course was also examined.

Results:

56.2%(59/105) of the patients had unnormal ALT

AST

or total TBil throughout the course of the disease

but in 91.4%(96/105) cases the level of ALT

AST or TBil ≤3 fold of the upper limit of normal reference range (ULN). The overall distribution of ALT

AST

and TBil were all significantly difference between mild and severe group (

0.05). The percentage of the patients with elevated both ALT and AST was 12.7%(10/79) in mild cases

. 46.2%(12/26) in severe cases (

=0.001). 34.6%(9/26) severe group patients started to have abnormal ALT after admission

and 73.3%(77/105) of all patients had normal ALT before discharge.

Conclusions:

Elevated liver function index is very common in patients with COVID-19 infection

and the level were less than 3×ULN

but most are reversible. The abnormality of 2 or more indexes is low in the patients with COVID-19

but it is more likely to occur in the severe group.

关键词

Keywords

references

Guan WJ , Ni ZY , Hu Y , Liang WH , Ou CQ , He JX , et al . Clinical Characteristics of Coronavirus Disease 2019 in China . N Engl J Med. 2020 . https://doi.org/10.1056/NEJMc2009226 https://doi.org/10.1056/NEJMc2009226 [Epub ahead of print] .

Chen N , Zhou M , Dong X , Qu J , Gong F , Han Y , et al . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study . Lancet. 2020 ; 395 : 507 – 13 .

Huang C , Wang Y , Li X , Ren L , Zhao J , Hu Y , et al . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China . Lancet. 2020 ; 395 : 497 – 506 .

Wang D , Hu B , Hu C , Zhu FF , Liu X , Zhang J , et al . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China . JAMA . 2020 . doi: https://doi.org/10.1001/jama.2020.1585-1585 https://doi.org/10.1001/jama.2020.1585-1585 . [Epub ahead of print] .

Shi HS , Han XY , Jiang NC , Cao YK , AlwalidO GJG , et al . Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: A descriptive study . Lancet Infect Dis. 2020 . https://doi.org/10.1016/S1473-3099(20)30086-4 https://doi.org/10.1016/S1473-3099(20)30086-4 [Epub ahead of print] .

National Health Commission of the People’s Republic of China . Guidelines for The Diagnosis and Treatment of Novel Coronavirus (2019- nCoV) Infection by The National Health Commission (trial version 6) ( 2020-03-07 )[EB/OL]. http://www.nhc.gov.cn/xcs/zhengcwj/202003/64856d5b0458141fa9f376853224d41d7.shtml http://www.nhc.gov.cn/xcs/zhengcwj/202003/64856d5b0458141fa9f376853224d41d7.shtml .

Yan J , Xie W , Ou WN , Zhao H , Wang SY , Wang JH , et al . Epidemiological survey and risk factor analysis of fatty liver disease of adult residents, Beijing, China . J Gastroenterol Hepatol. 2013 ; 28 : 1654 – 9 .

Guan GW , Gao L , Wang JW , Wen XJ , Mao TH , Peng SW , et al . Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia . Zhonghua Gan Zang Bing Za Zhi. 2020 ; 28 ( 2 ): 100 – 6 .

Xu Z , Shi L , Wang Y , Zhang J , Huang L , Zhang C , et al . Pathological findings of COVID-19 associated with acute respiratory distress syndrome . Lancet Respir Med. 2020 ; 8 ( 4 ): 420 – 2 .

Zhao Y , Zhao Z , Wang Y , Zhou Y , Ma Y , Zuo W . Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov . BioRxiv. 2020 . https://doi.org/10.1101/2020.02.11.20022228 https://doi.org/10.1101/2020.02.11.20022228 [Epub ahead of print] .

Yao N , Wang SN , Lian JQ , Sun YT , Zhang GF , Kang WZ , et al . Clinical characteristics and influencing factors of patients with novel coronavirus pneumonia combined with liver injury in Shaanxi region . Zhonghua Gan Zang Bing Za Zhi. 2020 ; 28 ( 3 ): 234 – 9 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak

Dynamic Stress Analysis on Speed-increase Subgrade of Existing Railway

Fracture Load Test and Spatial Analysis for the Full Scale Model of Underground Viaduct Channel Girder

Digital Demodulation Method for Multi-tone FM Signal in Track Circuit System

Analysis on the Reason of Larger Wheel/Rail Lateral Force for Loaded Car with 3D-axle Welded-frame Bogies during Negotiating

Related Author

Cong Xie

Yuan Shi

Cheng-Zhong Zheng

Si-Mao Fu

Long Chen

Ben-Qing Wu

Yu He

Feng Ye

Related Institution

Department of Pediatrics, the Second Affiliated Hospital of Guangzhou Medical University

Department of Pediatrics, Strategic Support Force Medical Center of PLA

Department of Pediatrics, Zhongshan Boai Hospital

Department of Neonatology, Children’s Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child/Development and Disorders/National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of Pediatrics

Department of Pediatrics, Military Hospital of 74 Group of PLA

⁰