Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial <italic style="font-style: italic">Acinetobacter baumannii</italic> infection after trauma: a case report and review of the literature

Li Zhong; Xue-Zhi Shi; Lei Su; Zhi-Feng Liu

doi:10.1186/s40779-020-00253-9

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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

CASE REPORT | Updated：2023-06-05

- Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature
- Military Medical Research Vol. 7, Issue 4, Pages: 497-502(2020)
- Affiliations：
  
  1.Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510515, China.
  2.Department of Critical Care Medicine, the First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang 550001, China.
  3.Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China.
  4.Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China.
- Author bio：
  
  * Zhifengliu7797@163.com
- Funds：
- DOI：10.1186/s40779-020-00253-9
  CLC：
- Published：2020-12
- Accepted：
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Zhong et al.: Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature. Mil Med Res, 2020, 7: 23.
DOI：

Zhong et al.: Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature. Mil Med Res, 2020, 7: 23. DOI： 10.1186/s40779-020-00253-9.

摘要

Abstract

Background:

Intracranial infection after craniotomy is one of the most serious postoperative complications

especially multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacterial meningitis

and strongly affects the prognosis of patients. Current treatment experience regarding these infections is scarce.

Case presentation:

We report a case of severe intracranial infection of XDR

Acinetobacter baumannii

(

A. baumannii

) that was treated by intravenous (IV) injection

sequential intraventricular (IVT) injection of tigecycline and polymyxin B

and other anti-infective drugs. Good results were obtained

and the patient was eventually discharged from the hospital. This case is characterized by intracranial infection.

Conclusions:

The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR

A. baumannii

. The tigecycline IVT pathway is also a safe treatment option.

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references

Fang C , Zhu T , Zhang P , Xia L , Sun CX . Risk factors of neurosurgical site infection after craniotomy: a systematic review and meta-analysis . Am J Infect Control . 2017 ; 45 ( 11 ): e123 - 4 .

3rd McClelland S , Hall WA . Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures . Clin Infect Dis . 2007 ; 45 ( 1 ): 55 - 9 .

Korinek AM , Baugnon T , Golmard JL , van Effenterre R , Coriat P , Puybasset L . Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis . Neurosurgery . 2008 ; 62 ( Suppl 2 ): 532 - 9 .

Thigpen MC , Whitney CG , Messonnier NE , Zell ER , Lynfield R , Hadler JL , et al . Bacterial meningitis in the United States, 1998-2007 . N Engl J Med . 2011 ; 364 ( 21 ): 2016 - 25 .

Karaiskos I , Galani L , Baziaka F , Giamarellou H . Intraventricular and intrathecal colistin as the last therapeutic resort for the treatment of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii ventriculitis and meningitis: a literature review . Int J Antimicrob Agents . 2013 ; 41 ( 6 ): 499 - 508 .

Kurtaran B , Kuscu F , Ulu A , Inal AS , Komur S , Kibar F , et al . The causes of postoperative meningitis: the comparison of gram-negative and grampositive pathogens . Turk Neurosurg . 2018 ; 28 ( 4 ): 589 - 96 .

Kim HI , Kim SW , Park GY , Kwon EG , Kim HH , Jeong JY , et al . The causes and treatment outcomes of 91 patients with adult nosocomial meningitis . Korean J Intern Med . 2012 ; 27 ( 2 ): 171 - 9 .

Huttova M , Freybergh PF , Rudinsky B , Sramka M , Kisac P , Bauer F , et al . Postsurgical meningitis caused by Acinetobacter baumannii associated with high mortality . Neuro Endocrinol Lett . 2007 ; 28 ( Suppl 2 ): 15 - 6 .

Metan G , Alp E , Aygen B , Sumerkan B . Acinetobacter baumannii meningitis in post-neurosurgical patients: clinical outcome and impact of carbapenem resistance . J Antimicrob Chemother . 2007 ; 60 ( 1 ): 197 - 9 .

Karageorgopoulos DE , Falagas ME . Current control and treatment of multidrug-resistant Acinetobacter baumannii infections . Lancet Infect Dis . 2008 ; 8 ( 12 ): 751 - 62 .

Nau R , Seele J , Djukic M , Eiffert H . Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections . Curr Opin Infect Dis . 2018 ; 31 ( 1 ): 57 - 68 .

Nau R , Sorgel F , Eiffert H . Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections . Clin Microbiol Rev . 2010 ; 23 ( 4 ): 858 - 83 .

De Bonis P , Lofrese G , Scoppettuolo G , Spanu T , Cultrera R , Labonia M , et al . Intraventricular versus intravenous colistin for the treatment of extensively drug resistant Acinetobacter baumannii meningitis . Eur J Neurol . 2016 ; 23 ( 1 ): 68 - 75 .

Wu Y , Chen K , Zhao J , Wang Q , Zhou J . Intraventricular administration of tigecycline for the treatment of multidrug-resistant bacterial meningitis after craniotomy: a case report . J Chemother . 2018 ; 30 ( 1 ): 49 - 52 .

Chen K , Wu Y , Wang Q , Wang J , Li X , Zhao Z , et al . The methodology and pharmacokinetics study of intraventricular administration of vancomycin in patients with intracranial infections after craniotomy . J Crit Care , 2015 , 30 ( 1 ): 218.e211 - 5 .

Wu Y , Kang J , Wang Q . Drug concentrations in the serum and cerebrospinal fluid of patients treated with norvancomycin after craniotomy . Eur J Clin Microbiol Infect Dis . 2017 ; 36 ( 2 ): 305 - 11 .

Kim BN , Peleg AY , Lodise TP , Lipman J , Li J , Nation R , et al . Management of meningitis due to antibiotic-resistant Acinetobacter species . Lancet Infect Dis . 2009 ; 9 ( 4 ): 245 - 55 .

Huang CR , Chen SF , Lu CH , Chuang YC , Tsai NW , Chang CC , et al . Clinical characteristics and therapeutic outcomes of nosocomial super-infection in adult bacterial meningitis . BMC Infect Dis . 2011 ; 11 : 133 .

De Pascale G , Pompucci A , Maviglia R , Spanu T , Bello G , Mangiola A , et al . Successful treatment of multidrug-resistant Acinetobacter baumannii ventriculitis with intrathecal and intravenous colistin . Minerva Anestesiol . 2010 ; 76 ( 11 ): 957 - 60 .

Tunkel AR , Hasbun R , Bhimraj A , Byers K , Kaplan SL , Scheld WM , et al . 2017 Infectious Diseases Society of America's clinical practice guidelines for healthcare-associated ventriculitis and meningitis . Clin Infect Dis . 2017 ; 64 ( 6 ): e34 - 65 .

Rodvold KA , Gotfried MH , Cwik M , Korth-Bradley J , Dukart G , Ellis-Grosse EJ . Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose . J Antimicrob Chemother . 2006 ; 58 ( 6 ): 1221 - 9 .

Ray L , Levasseur K , Nicolau DP , Scheetz MH . Cerebral spinal fluid penetration of tigecycline in a patient with Acinetobacter baumannii cerebritis . Ann Pharmacother . 2010 ; 44 ( 3 ): 582 - 6 .

Tutuncu EE , Kuscu F , Gurbuz Y , Ozturk B , Haykir A , Sencan I . Tigecycline use in two cases with multidrug-resistant Acinetobacter baumannii meningitis . Int J Infect Dis . 2010 ; 14 ( Suppl 3 ): e224 - 6 .

Lauretti L , D'Alessandris QG , Fantoni M , D'Inzeo T , Fernandez E , Pallini R , et al . First reported case of intraventricular tigecycline for meningitis from extremely drug-resistant Acinetobacter baumannii . J Neurosurg . 2017 ; 127 ( 2 ): 370 - 3 .

Fang YQ , Zhan RC , Jia W , Zhang BQ , Wang JJ . A case report of intraventricular tigecycline therapy for intracranial infection with extremely drug resistant Acinetobacter baumannii . Medicine(Baltimore) . 2017 ; 96 ( 31 ): e7703 .

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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

DOI：10.1186/s40779-020-00253-9

摘要

Abstract

关键词

Keywords

references