Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study

Lan Wu; Bing-Hui Li; Yun-Yun Wang; Chao-Yang Wang; Hao Zi; Hong Weng; Qiao Huang; You-Jia Zhu; Xian-Tao Zeng

doi:10.1186/s40779-019-0223-8

Your Location：

Home >

Browse articles >

Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study

RESEARCH | Updated：2023-06-05

- Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study
- Military Medical Research Vol. 7, Issue 2, Pages: 157-165(2020)
- Affiliations：
  
  1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  3.Center for Evidence-Based Medicine, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng 475000, China
  4.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
- Author bio：
  
  * Zhuyoujia1954@sina.com;
  zengxiantao1128@163.com; zengxiantao1128@gmail.com
- Funds：
- DOI：10.1186/s40779-019-0223-8
  CLC：
- Published：2020-06
- Accepted：
Scan QR Code
Cite this article as: Wu et al.: Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study. Mil Med Res, 2019, 6: 34
DOI：

Cite this article as: Wu et al.: Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study. Mil Med Res, 2019, 6: 34 DOI： 10.1186/s40779-019-0223-8.

摘要

Abstract

Background:

Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence

this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia.

Methods:

A total of 4930 participants were selected from an available health examination that was carried out in 2017

only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups

the benign prostatic hyperplasia group was then divided into prostate volume ≤60 g and >60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0)

periodontal disease (CPI score between 1 and 4)

and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software.

Results:

A total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (

=1.68

95% CI: 1.26–2.24)

and individuals with periodontitis showed a higher risk (

=4.18

95% CI: 2.75–6.35). In addition

among matched cases and controls

this association remained robust (periodontal disease:

=1.85

95% CI: 1.30–2.64; periodontitis:

=4.83

95% CI: 2.57–9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤60 g:

=1.64

95% CI: 1.22–2.20; for volume

60 g:

=2.17

95% CI: 1.04–4.53)

and there was a higher risk in the group with a prostate volume greater than 60 g.

Conclusions:

Periodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.

关键词

Keywords

references

Kassebaum NJ , Smith AGC , Bernabe E , Fleming TD , Reynolds AE , Vos T , et al . Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, and risk factors . J Dent Res. 2017 ; 96 ( 4 ): 380 – 7 .

Zhang Q , Li Z , Wang C , Liu Y , Yang Y , Bussell S , et al . A comparison of DALYs for periodontal disease in China between 1990 and 2013: insights from the 2013 global burden of disease study . BMC Oral Health. 2017 ; 17 ( 1 ): 74 .

Mustapha IZ , Sarah D , Michael O , Richard U . Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis . J Periodontol. 2007 ; 78 ( 12 ): 2289 – 302 .

Johar N , Dhodapkar SV , Kumar R , Verma T , Jajoo A . Association of relationship between periodontal disease and cardiovascular disease . Mymensingh Med J. 2017 ; 26 ( 2 ): 439 – 47 .

Schmitt A , Carra MC , Boutouyrie P , Bouchard P . Periodontitis and arterial stiffness: a systematic review and meta-analysis . J Clin Periodontol. 2016 ; 42 ( 11 ): 977 – 87 .

Orlandi M , Suvan J , Petrie A , Donos N , Masi S , Hingorani A , et al . Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis . Atherosclerosis. 2014 ; 236 ( 1 ): 39 – 46 .

Zeng XT , Leng WD , Lam YY , Yan BP , Wei XM , Weng H , et al . Periodontal disease and carotid atherosclerosis: a meta-analysis of 17,330 participants . Int J Cardiol. 2016 ; 203 : 1044 – 51 .

Lafon A , Pereira B , Dufour T , Rigouby V , Giroud M , Béjot Y , et al . Periodontal disease and stroke: a meta-analysis of cohort studies . Eur J Neurol. 2014 ; 21 ( 9 ): 1155–61.e66-7 .

Leng WD , Zeng XT , Kwong JS , Hua XP . Periodontal disease and risk of coronary heart disease: an updated meta-analysis of prospective cohort studies . Int J Cardiol. 2015 ; 201 : 469 – 72 .

Doostiirani A , Cheraghi Z . Chronic periodontitis and the risk of erectile dysfunction: a systematic review and meta-analysis: methodological issues . Int J Impot Res. 2017 ; 29 ( 6 ): 262 .

Martin-Cabezas R , Seelam N , Petit C , Agossa K , Gaertner S , Tenenbaum H , et al . Association between periodontitis and arterial hypertension: a systematic review and meta-analysis . Am Heart J. 2016 ; 180 : 98 – 112 .

Zhao MJ , Qiao YX , Wu L , Huang Q , Li BH , Zeng XT . Periodontal disease is associated with increased risk of hypertension: a cross-sectional study . Front Physiol. 2019 ; 10 : 440 .

Zeng XT , Deng AP , Li C , Xia LY , Niu YM , Leng WD . Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies . PLoS One. 2013 ; 8 ( 10 ): e79017 .

Shao J , Wu L , Leng WD , Fang C , Zhu YJ , Jin YH , et al . Periodontal disease and breast cancer: a meta-analysis of 1,73,162 participants . Front Oncol. 2018 ; 8 : 601 .

Zeng XT , Xia LY , Zhang YG , Li S , Leng WD , Kwong JS . Periodontal disease and incident lung cancer risk: a meta-analysis of cohort studies . J Periodontol. 2016 ; 87 ( 10 ): 1158 – 64 .

Maisonneuve P , Amar S , Lowenfels AB . Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis . Ann Oncol. 2017 ; 28 ( 5 ): 985 – 95 .

Graziani F , Gennai S , Solini A , Petrini M . A systematic review and metaanalysis of epidemiologic observational evidence on the effect of periodontitis on diabetes an update of the EFP-AAP review . J Clin Periodontol. 2018 ; 45 ( 2 ): 167 – 87 .

Papageorgiou SN , Christoph R , Andreas JG , James D . Effect of overweight/obesity on response to periodontal treatment: systematic review and a meta-analysis . J Clin Periodontol. 2015 ; 42 ( 3 ): 247 – 61 .

Abariga SA , Whitcomb BW . Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies . BMC Pregnancy Childbirth. 2016 ; 16 ( 1 ): 344 .

Camille V , Loughlin KR . Benign prostatic hyperplasia: epidemiology, economics and evaluation . Can J Urol. 2015 ; 22 ( 1 ): 1 – 6 .

Lee SWH , Chan EMC , Lai YK . The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a systematic review and meta-analysis . Sci Rep. 2017 ; 7 ( 1 ): 7984 .

Taub DA , Wei JT . The economics of benign prostatic hyperplasia and lower urinary tract symptoms in the United States . Curr Urol Rep. 2006 ; 7 ( 4 ): 272 .

Boland MR , Hripcsak G , Albers DJ , Wei Y , Wilcox AB , Wei J , et al . Discovering medical conditions associated with periodontitis using linked electronic health records . J Clin Periodontol. 2013 ; 40 ( 5 ): 474 – 82 .

Estemalik J , Demko C , Bissada NF , Joshi N , Bodner D , Shankar E , et al . Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases . J Periodontol. 2017 ; 88 ( 9 ): 823 – 9 .

von Elm E , Altman DG , Egger M , Pocock SJ , Gotzsche PC , Vandenbroucke JP . The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies . Int J Surg. 2014 ; 12 ( 12 ): 1495 – 9 .

CRHA , CPAM , The Project Team for Minimally Invasive Plasmakinetic System and Cloud Planning Solution of The National Key Research and Development Program of China . Transurethral bipolar plasmakinetic prostatectomy treatment for benign prostatic hyperplasia in Chinese: development of a national evidence-based clinical practice guideline (2018 standard version) . Natl Med J Chin. 2018 ; 98 ( 20 ): 1549 – 60 .

Holborow DW . The community periodontal index of treatment needs-uses and abuses? N Z Dent J. 1998 ; 94 ( 417 ): 120 – 1 .

Cutress TW , Ainamo J , Sardo-Infirri J . The community periodontal index of treatment needs (CPITN) procedure for population groups and individuals . Int Dent J. 1987 ; 37 ( 4 ): 222 – 33 .

Martin SA , Haren MT , Marshall VR , Lange K , Wittert GA , Members of the Florey Adelaide Male Ageing Study . Prevalence and factors associated with uncomplicated storage and voiding lower urinary tract symptoms in community-dwelling Australian men . World J Urol. 2011 ; 29 ( 2 ): 179 – 84 .

Ebersole JL , Graves CL , Gonzalez OA , Morford LA , Huja PE , Jr HJ , et al . Aging, inflammation, immunity and periodontal disease . Periodontology. 2016 ; 72 ( 1 ): 54 – 75 .

Bourke JB , Griffin JP . Hypertension, diabetes mellitus, and blood groups in benign prostatic hypertrophy . BJU Int. 2010 ; 38 ( 1 ): 18 – 23 .

Zhao MJ , Huang Q , Wang XH , Ren XY , Jin YH , Zeng XT . Comparing clinical parameters of abnormal and normal fasting blood glucose in benign prostatic hyperplasia patients . Aging Male . 2019 : 1 – 8 . https://doi.org/10.1080/13685538.2019.1570493https://doi.org/10.1080/13685538.2019.1570493 https://doi.org/10.1080/13685538.2019.1570493https://doi.org/10.1080/13685538.2019.1570493 .

Shih HJ , Huang CJ , Lin JA , Kao MC , Fan YC , Tsai PS . Hyperlipidemia is associated with an increased risk of clinical benign prostatic hyperplasia . Prostate. 2018 ; 78 ( 2 ): 113 – 20 .

Zorba Oü , Uzun H , Önem K , Çetinkaya M , Rifaioǧlu M , Akça N . Association between prostate volume and red cell distribution width . Low Urin Tract Symptoms. 2014 ; 6 ( 1 ): 52 – 6 .

Li BH , Deng T , Huang Q , Zi H , Weng H , Zeng XT . Body mass index and risk of prostate volume, international prostate symptom score, maximum urinary flow rate, and post-void residual in benign prostatic hyperplasia patients . Am J Mens Health. 2019 ; 13 ( 4 ): 1557988319870382 .

Mojon P . Oral health and respiratory infection . J Can Dent Assoc. 2002 ; 68 ( 6 ): 340 – 5 .

Pihlstrom BL , Michalowicz BS , Johnson NW . Periodontal diseases . Lancet. 2005 ; 366 ( 9499 ): 1809 – 20 .

Coulthwaite L , Verran J . Potential pathogenic aspects of denture plaque . Br J Biomed Sci. 2007 ; 64 ( 4 ): 180 – 9 .

De Nunzio C , Presicce F , Tubaro A . Inflammatory mediators in the development and progression of benign prostatic hyperplasia . Nat Rev Urol. 2016 ; 13 ( 10 ): 613 – 26 .

Norström MM , Rådestad E , Sundberg B , Mattsson J , Henningsohn L , Levitsky V , et al . Progression of benign prostatic hyperplasia is associated with proinflammatory mediators and chronic activation of prostate-infiltrating lymphocytes . Oncotarget. 2016 ; 7 ( 17 ): 23581 – 93 .

Cakir SS , Polat EC , Ozcan L , Besiroglu H , Ötunctemur A , Ozbek E . The effect of prostatic inflammation on clinical outcomes in patients with benign prostate hyperplasia . Prostate Int. 2018 ; 6 ( 2 ): 71 – 4 .

Maekawa T , Takahashi N , Tabeta K , Aoki Y , Miyashita H , Miyauchi S , et al . Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile . PLoS One. 2011 ; 6 ( 5 ): e20240 .

Guo H , Ren H , Liang S , Ji Y , Jiang H , Zhang P , et al . Phosphatidylinositol 3-Kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis . Mol Immunol. 2018 ; 104 : 100 – 7 .

Wu Z , Ni J , Liu Y , Teeling JL , Takayama F , Collcutt A , et al . Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice . Brain Behav Immun. 2017 ; 65 : 350 – 61 .

Chen Y , Zhou R , Yi Z , Li Y , Fu Y , Zhang Y , et al . Porphyromonas gingivalisinduced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl-2/Bax/Caspase-3 signaling pathway . Mol Med Rep. 2018 ; 18 ( 1 ): 97 – 104 .

Xu H , Fu S , Chen Y , Chen Q , Gu M , Wang Z . Smoking habits and benign prostatic hyperplasia: a systematic review and meta-analysis of observational studies . Medicine (Baltimore). 2016 ; 95 ( 32 ): e4565 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Association between periodontal disease and systemic diseases: a cross-sectional analysis of current evidence

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

Explosive eye injuries: characteristics, traumatic mechanisms, and prognostic factors for poor visual outcomes

Research on the Measurement System of the Attack Angle between Wheel and Rail Based on Image Identification

Research on Reinforcement Technique to Enhance Lateral Stiffness of Steel Truss Bridge on Existing Railway

Related Author

Bin Ma

Xia Zhou

Wen-Zhong Xie

Bing-Hui Li

Yun-Yun Wang

Di Huang

Xia Zhou

Bin Ma

Related Institution

Research Center for Medical Device Regulatory Science, Lanzhou University

Department of Stomatology, Daping Hospital, Army Medical University

Henan Provincial Engineering Research Center for Microecological Regulatory of Oral Environment and Oral Implantology, Kaifeng University Health Science Center

Center for Evidence-Based and Trans-lational Medicine, Zhongnan Hospital of Wuhan University

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University

⁰