Application of stem cells in tissue engineering for defense medicine

Chinedu Cletus Ude; Azizi Miskon; Ruszymah Bt Hj Idrus; Muhamad Bin Abu Bakar

doi:10.1186/s40779-018-0154-9

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Application of stem cells in tissue engineering for defense medicine

REVIEW | Updated：2026-03-12

- Application of stem cells in tissue engineering for defense medicine
- Military Medical Research Vol. 5, Issue 2, Pages: 140-158(2018)
- Affiliations：
  
  1.Bio-artifical Organ and Regenerative Medicine Unit, National Defence University of Malaysia, Sungai Besi Camp, 57000 Kuala Lumpur, Malaysia
  2.Department of Physiology, Pre-clinical Block, National University of Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia
- Author bio：
  
  *: azizimis@gmail.com; azizimiskon@upnm.edu.my
- Funds：
- DOI：10.1186/s40779-018-0154-9
  CLC：
- Published：2018-06
- Accepted：
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Ude et al.: Application of stem cells in tissue engineering for defense medicine. Mil Med Res, 2018, 5: 7
DOI：

Ude et al.: Application of stem cells in tissue engineering for defense medicine. Mil Med Res, 2018, 5: 7 DOI： 10.1186/s40779-018-0154-9.

摘要

Abstract

The dynamic nature of modern warfare

including threats and injuries faced by soldiers

necessitates the development of countermeasures that address a wide variety of injuries. Tissue engineering has emerged as a field with the potential to provide contemporary solutions. In this review

discussions focus on the applications of stem cells in tissue engineering to address health risks frequently faced by combatants at war. Human development depends intimately on stem cells

the mysterious precursor to every kind of cell in the body that

with proper instruction

can grow and differentiate into any new tissue or organ. Recent reports have suggested the greater therapeutic effects of the anti-inflammatory

trophic

paracrine and immune-modulatory functions associated with these cells

which induce them to restore normal healing and tissue regeneration by modulating immune reactions

regulating inflammation

and suppressing fibrosis. Therefore

the use of stem cells holds significant promise for the treatment of many battlefield injuries and their complications. These applications include the treatment of injuries to the skin

sensory organs

nervous system tissues

the musculoskeletal system

circulatory/pulmonary tissues and genitals/testicles and of acute radiation syndrome and the development of novel biosensors. The new research developments in these areas suggest that solutions are being developed to reduce critical consequences of wounds and exposures suffered in warfare. Current military applications of stem cell-based therapies are already saving the lives of soldiers who would have died in previous conflicts. Injuries that would have resulted in deaths previously now result in wounds today; similarly

today’s permanent wounds may be reduced to tomorrow’s bad memories with further advances in stem cell-based therapies.

关键词

Keywords

references

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