Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts

Jin-Hu Guo; Wei-Min Qu; Shan-Guang Chen; Xiao-Ping Chen; Ke Lv; Zhi-Li Huang; Yi-Lan Wu

doi:10.1186/2054-9369-1-23

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Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts

PERSPECTIVE | Updated：2026-03-12

- Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts
- Military Medical Research Vol. 1, Issue 3, Pages: 143-149(2014)
- Affiliations：
  
  1.Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China
  2.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
  3.National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094, China
  4.State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China
- Author bio：
  
  *: guojinhu@mail.sysu.edu.cn;
  quweimin@fudan.edu.cn
- Funds：
- DOI：10.1186/2054-9369-1-23
  CLC：
- Published：2014-09
- Accepted：
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Guo et al.:Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Mil Med Res 2014, 1: 23
DOI：

Guo et al.:Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Mil Med Res 2014, 1: 23 DOI： 10.1186/2054-9369-1-23.

摘要

Abstract

The circadian clock and sleep are essential for human physiology and behavior; deregulation of circadian rhythms impairs health and performance. Circadian clocks and sleep evolved to adapt to Earth’s environment

which is characterized by a 24-hour light–dark cycle. Changes in gravity load

lighting and work schedules during spaceflight missions can impact circadian clocks and disrupt sleep

in turn jeopardizing the mood

cognition and performance of orbiting astronauts. In this review

we summarize our understanding of both the influence of the space environment on the circadian timing system and sleep and the impact of these changes on astronaut physiology and performance.

关键词

Keywords

references

Mcphee JC , Charles JB : Human health and performance risks of space exploration missions: evidence reviewed by the NASA human research program . Houston : National Aeronautics and Space Administration ; 2009 .

Chen S : Advances in Human Space Research - Lessons Learned and Future Directions . In A Sponsored Supplement to Science: Human Performance in Space - Advancing Astronautics Research in China . Edited by Donald K . Washington DC : AAAS Press ; 2014 : 2 .

Bell-Pedersen D , Cassone VM , Earnest DJ , Golden SS , Hardin PE , Thomas TL , Zoran MJ : Circadian rhythms from multiple oscillators: lessons from diverse organisms . Nat Rev Genet 2005 , 6 : 544 - 556 .

Van Dongen HP , Dinges DF : Sleep, circadian rhythms, and psychomotor vigilance . Clin Sports Med 2005 , 24 : 237–249. vii-viii

Mohawk JA , Green CB , Takahashi JS : Central and peripheral circadian clocks in mammals . Annu Rev Neurosci 2012 , 35 : 445 - 462 .

Kolla BP , Auger RR : Jet lag and shift work sleep disorders: how to help reset the internal clock . Cleve Clin J Med 2011 , 78 : 675 - 684 .

Newman DJ , Lathan CE : Memory processes and motor control in extreme environments . IEEE Trans Syst Man Cybern C Appl Rev 1999 , 29 : 387 - 394 .

Roenneberg T , Merrow M : Circadian clocks - the fall and rise of physiology . Nat Rev Mol Cell Biol 2005 , 6 : 965 - 971 .

Jud C , Schmutz I , Hampp G , Oster H , Albrecht U : A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions . Biol Proced Online 2005 , 7 : 101 - 116 .

Wirz-Justice A , Schmid AC , Graw P , Krauchi K , Kielholz P , Poldinger W , Fisch HU , Buddeberg C : Dose relationships of morning bright white light in seasonal affective disorders (SAD) . Experientia 1987 , 43 : 574 - 576 .

Stenberg D : Neuroanatomy and neurochemistry of sleep . Cell Mol Life Sci 2007 , 64 : 1187 - 1204 .

Steininger TL , Alam MN , Gong H , Szymusiak R , McGinty D : Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat . Brain Res 1999 , 840 : 138 - 147 .

Fornal C , Auerbach S , Jacobs BL : Activity of serotonin-containing neurons in nucleus raphe magnus in freely moving cats . Exp Neurol 1985 , 88 : 590 - 608 .

Lee MG , Hassani OK , Alonso A , Jones BE : Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep . J Neurosci 2005 , 25 : 4365 - 4369 .

Sherin JE , Elmquist JK , Torrealba F , Saper CB : Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat . J Neurosci 1998 , 18 : 4705 - 4721 .

Szymusiak R , Alam N , Steininger TL , McGinty D : Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats . Brain Res 1998 , 803 : 178 - 188 .

Huang ZL , Urade Y , Hayaishi O : The role of adenosine in the regulation of sleep . Curr Top Med Chem 2011 , 11 : 1047 – 1057 .

Saper CB , Scammell TE , Lu J : Hypothalamic regulation of sleep and circadian rhythms . Nature 2005 , 437 : 1257 – 1263 .

Chou TC , Bjorkum AA , Gaus SE , Lu J , Scammell TE , Saper CB : Afferents to the ventrolateral preoptic nucleus . J Neurosci 2002 , 22 : 977 - 990 .

Sakurai T , Nagata R , Yamanaka A , Kawamura H , Tsujino N , Muraki Y , Kageyama H , Kunita S , Takahashi S , Goto K , Koyama Y , Shioda S , Yanagisawa M : Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice . Neuron 2005 , 46 : 297 - 308 .

Watts AG , Swanson LW , Sanchez-Watts G : Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat . J Comp Neurol 1987 , 258 : 204 - 229 .

Chou TC , Scammell TE , Gooley JJ , Gaus SE , Saper CB , Lu J : Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms . J Neurosci 2003 , 23 : 10691 - 10702 .

Lu J , Zhang YH , Chou TC , Gaus SE , Elmquist JK , Shiromani P , Saper CB : Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation . J Neurosci 2001 , 21 : 4864 - 4874 .

Lo JC , Groeger JA , Santhi N , Arbon EL , Lazar AS , Hasan S , von Schantz M , Archer SN , Dijk DJ : Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase . PLoS One 2012 , 7 : e45987 .

Manfredini R , Manfredini F , Fersini C , Conconi F : Circadian rhythms, athletic performance, and jet lag . Br J Sports Med 1998 , 32 : 101 - 106 .

Bechtold DA , Gibbs JE , Loudon AS : Circadian dysfunction in disease . Trends Pharmacol Sci 2010 , 31 : 191 - 198 .

Haus EL , Smolensky MH : Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation . Sleep Med Rev 2013 , 17 : 273 - 284 .

Doran SM , Van Dongen HP , Dinges DF : Sustained attention performance during sleep deprivation: evidence of state instability . Arch Ital Biol 2001 , 139 : 253 - 267 .

Williamson A , Lombardi DA , Folkard S , Stutts J , Courtney TK , Connor JL : The link between fatigue and safety . Accid Anal Prev 2011 , 43 : 498 - 515 .

Murphy BA , Wagner AL , McGlynn OF , Kharazyan F , Browne JA , Elliott JA : Exercise influences circadian gene expression in equine skeletal muscle . Vet J 2014 , 201 : 39 - 45 .

Okamoto A , Yamamoto T , Matsumura R , Node K , Akashi M : An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression . J Circadian Rhythms 2013 , 11 : 10 .

Baron KG , Reid KJ : Circadian misalignment and health . Int Rev Psychiatry 2014 , 26 : 139 - 154 .

Ferraro JS , Fuller CA , Sulzman FM : The biological clock of Neurospora in a microgravity environment . Adv Space Res 1989 , 9 : 251 - 260 .

Hoban-Higgins TM , Alpatov AM , Wassmer GT , Rietveld WJ , Fuller CA : Gravity and light effects on the circadian clock of a desert beetle, Trigonoscelis gigas . J Insect Physiol 2003 , 49 : 671 - 675 .

Mergenhagen D , Mergenhagen E : The biological clock of Chlamydomonas reinhardii in space . Eur J Cell Biol 1987 , 43 : 203 - 207 .

Monk TH , Buysse DJ , Billy BD , Kennedy KS , Willrich LM : Sleep and circadian rhythms in four orbiting astronauts . J Biol Rhythms 1998 , 13 : 188 - 201 .

Sulzman FM , Ferraro JS , Fuller CA , Moore-Ede MC , Klimovitsky V , Magedov V , Alpatov AM : Thermoregulatory responses of rhesus monkeys during spaceflight . Physiol Behav 1992 , 51 : 585 - 591 .

Ruyters G , Friedrich U : From the Bremen Drop Tower to the international space station ISS – Ways to weightlessness in the German space life sciences program . Signal Transduct 2006 , 6 : 397 - 405 .

Bliss VL , Heppner FH : Circadian activity rhythm influenced by near zero magnetic field . Nature 1976 , 261 : 411 - 412 .

Wever R : The effects of electric fields on circadian rhythmicity in men . Life Sci Space Res 1970 , 8 : 177 - 187 .

Fuller CA , Murakami DM , Sulzman FM : Gravitational biology and the mammalian circadian timing system . Adv Space Res 1989 , 9 : 283 - 292 .

Michikami D , Kamiya A , Fu Q , Niimi Y , Iwase S , Mano T , Suzumura A : Effect of simulated microgravity exposure on thermoregulatory control of sweating . Environ Med 2001 , 45 : 58 - 61 .

Mizuno K , Inoue Y , Tanaka H , Komada Y , Saito H , Mishima K , Shirakawa S : Heart rate variability under acute simulated microgravity during daytime waking state and nocturnal sleep: comparison of horizontal and 6 degrees head-down bed rest . Neurosci Lett 2005 , 383 : 115 - 120 .

Shiraishi M , Kamo T , Nemoto S , Narita M , Kamegai M , Baevsky RM , Funtova II : Blood pressure variability during 120-day head-down bed rest in humans . Biomed Pharmacother 2003 , 57 ( Suppl 1 ): 35s - 38s .

Monk TH , Kennedy KS , Rose LR , Linenger JM : Decreased human circadian pacemaker influence after 100 days in space: a case study . Psychosom Med 2001 , 63 : 881 - 885 .

Basner M , Dinges DF , Mollicone D , Ecker A , Jones CW , Hyder EC , Di Antonio A , Savelev I , Kan K , Goel N , Morukov BV , Sutton JP : Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing . Proc Natl Acad Sci U S A 2013 , 110 : 2635 - 2640 .

Casler JG , Cook JR : Cognitive performance in space and analogous environments . Int J Cogn Ergon 1999 , 3 : 351 - 372 .

Fischer D , Arbeille P , Shoemaker JK , O’Leary DD , Hughson RL : Altered hormonal regulation and blood flow distribution with cardiovascular deconditioning after short-duration head down bed rest . J Appl Physiol (1985) 2007 , 103 : 2018 - 2025 .

Dijk DJ , Neri DF , Wyatt JK , Ronda JM , Riel E , Ritz-De Cecco A , Hughes RJ , Elliott AR , Prisk GK , West JB , Czeisler CA : Sleep, performance, circadian rhythms, and light–dark cycles during two space shuttle flights . Am J Physiol Regul Integr Comp Physiol 2001 , 281 : R1647 - R1664 .

Liang X , Zhang L , Wan Y , Yu X , Guo Y , Chen X , Tan C , Huang T , Shen H , Chen X , Li H , Lv K , Sun F , Chen S , Guo J : Changes in the diurnal rhythms during a 45-day head-down bed rest . PLoS One 2012 , 7 : e47984 .

Liang X , Zhang L , Shen H , Chen X , Wan Y , Li L , Liang L , Yu X , Guo Y , Yu J , Shu W , Tan C , Lv K , Xiao Y , Chen X , Chen S , Guo J : Effects of a 45-day head-down bed rest on the diurnal rhythms of activity, sleep and heart rate . Biol Rhythm Res 2014 , 45 : 596 - 601 .

Manzey D , Lorenz B : Mental performance during short-term and long-term spaceflight . Brain Res Brain Res Rev 1998 , 28 : 215 - 221 .

Czeisler CA , Gooley JJ : Sleep and circadian rhythms in humans . Cold Spring Harb Symp Quant Biol 2007 , 72 : 579 - 597 .

Burgess HJ , Legasto CS , Fogg LF , Smith MR : Can small shifts in circadian phase affect performance? Appl Ergon 2013 , 44 : 109 - 111 .

Santy PA , Kapanka H , Davis JR , Stewart DF : Analysis of sleep on Shuttle missions . Aviat Space Environ Med 1988 , 59 : 1094 - 1097 .

Putcha LBK , Marshburn TH , Ortega HJ , Billica RD : Pharmaceutical use by U.S. astronauts on space shuttle missions . Aviat Space Environ Med 1990 , 70 : 705 - 708 .

Barger LK , Flynn-Evans EE , Kubey A , Walsh L , Ronda JM , Wang W , Wright KP Jr , Czeisler CA : Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study . Lancet Neurol 2014 , 13 : 904 - 912 .

Gundel A , Polyakov VV , Zulley J : The alteration of human sleep and circadian rhythms during spaceflight . J Sleep Res 1997 , 6 : 1 - 8 .

Weigmann DA , Shappell SA : A Human Error Approach to Aviation Accident Analysis: the Human Factors Analysis and Classifi Cation System . Aldershot : Ashgate Publishing Company ; 2003 .

Holley DC , DeRoshia CW , Moran MM , Wade CE : Chronic centrifugation (hypergravity) disrupts the circadian system of the rat . J Appl Physiol (1985) 2003 , 95 : 1266 - 1278 .

Benke T , Koserenko O , Watson NV , Gerstenbrand F : Space and cognition: the measurement of behavioral functions during a 6-day space mission . Aviat Space Environ Med 1993 , 64 : 376 - 379 .

Mallis MM , DeRoshia CW : Circadian rhythms, sleep, and performance in space . Aviat Space Environ Med 2005 , 76 : B94 - B107 .

West KE , Jablonski MR , Warfield B , Cecil KS , James M , Ayers MA , Maida J , Bowen C , Sliney DH , Rollag MD , Hanifin JP , Brainard GC : Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans . J Appl Physiol (1985) 2011 , 110 : 619 - 626 .

Fucci RL , Gardner J , Hanifin JP , Jasser S , Byrne B , Gerner E , Rollag M , Brainard GC : Toward optimizing lighting as a countermeasure to sleep and circadian disruption in space flight . Acta Astronaut 2005 , 56 : 1017 - 1024 .

Wright KP Jr , Hughes RJ , Kronauer RE , Dijk DJ , Czeisler CA : Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans . Proc Natl Acad Sci U S A 2001 , 98 : 14027 - 14032 .

Scheer FA , Wright KP Jr , Kronauer RE , Czeisler CA : Plasticity of the intrinsic period of the human circadian timing system . PLoS One 2007 , 2 : e721 .

Barger LK , Sullivan JP , Vincent AS , Fiedler ER , McKenna LM , Flynn-Evans EE , Gilliland K , Sipes WE , Smith PH , Brainard GC , Lockley SW : Learning to live on a Mars day: fatigue countermeasures during the Phoenix Mars Lander mission . Sleep 2012 , 35 : 1423 - 1435 .

Czeisler CA , Duffy JF , Shanahan TL , Brown EN , Mitchell JF , Rimmer DW , Ronda JM , Silva EJ , Allan JS , Emens JS , Dijk DJ , Kronauer RE : Stability, precision, and near-24-hour period of the human circadian pacemaker . Science 1999 , 284 : 2177 - 2181 .

Aschoff J : Circadian Rhythms in Man: a self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity . Science 1965 , 148 : 1427 - 1432 .

Lewis PR , Lobban MC : The effects of prolonged periods of life on abnormal time routines upon excretory rhythms in human subjects . Q J Exp Physiol Cogn Med Sci 1957 , 42 : 356 - 371 .

Sandal GM : Psychosocial issues in space: future challenges . Gravit Space Biol Bull 2001 , 14 : 47 - 54 .

Wang D , Zhang L , Liang X , Shen H , Chen X , Wan Y , Guo J : Space Meets Time: Impact of Gravity on Circadian/Diurnal Rhythms . In A Sponsored Supplement to Science: Human Performance in Space - Advancing Astronautics Research in China . Edited by Donald K . Washington DC : AAAS Press ; 2014 : 15 – 17 .

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