Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

Jing Feng; Yan-Hong Liu; Li-Ming Gong; Wen-Xuan Zhang; Chen-Fei Liu; Cong-Cong Xiao; Li-Qing Chen; Ming-Ji Jin; You-Yan Guan; Zhong-Gao Gao; Wei Huang

doi:10.1016/j.mmr.2026.100036

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Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

RESEARCH | Updated：2026-06-12

- Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer
- Military Medical Research (2026)
- Affiliations：
  
  State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Beijing Key Laboratory of Key Technologies for Natural Drug Delivery and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Department of Pharmacy, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou 215000, Jiangsu, China
  Department of Urology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Author bio：
  
  *Corresponding author: You-Yan Guan, guanyouyan@cicams.ac.cn;
  Zhong-Gao Gao, zggao@imm.ac.cn;
  Wei Huang, huangwei@imm.ac.cn
- Funds：
- DOI：10.1016/j.mmr.2026.100036
  CLC：
- Received：12 May 2025，
  
  Accepted：19 April 2026，
  
  Published：2026-05
- Accepted：
Scan QR Code
Feng J, Liu YH, Gong LM, Zhang WX, Liu CF, Xiao CC, et al. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer. Mil Med Res. 2026;13(1):100036.
DOI：

Feng J, Liu YH, Gong LM, Zhang WX, Liu CF, Xiao CC, et al. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer. Mil Med Res. 2026;13(1):100036. DOI： 10.1016/j.mmr.2026.100036.

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Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

DOI：10.1016/j.mmr.2026.100036