Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant <italic style="font-style: italic">Staphylococcus aureus</italic> (MRSA)

Volker Micheel; Benedikt Hogan; Thomas Köller; Philipp Warnke; Sabine Crusius; Rebecca Hinz; Ralf Matthias Hagen; Norbert Georg Schwarz; Hagen Frickmann

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Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)

RESEARCH | Updated：2026-03-12

- Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)
- Military Medical Research Vol. 2, Issue 4, Pages: 213-219(2015)
- Affiliations：
  
  1.Department of Tropical Medicine at the Bernhard Nocht Institute, German Armed Forces Hospital of Hamburg, Hamburg, Germany
  2.Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany
  3.Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany
- Author bio：
  
  *: frickmann@bni-hamburg.de
- Funds：
- DOI：
  CLC：
- Published：2015-12
- Accepted：
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Volker Micheel, Benedikt Hogan, Thomas Köller, et al. Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)[J]. Military Medical Research, 2015, 2(4): 213-219.
DOI：

Volker Micheel, Benedikt Hogan, Thomas Köller, et al. Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)[J]. Military Medical Research, 2015, 2(4): 213-219. DOI：

摘要

Abstract

Background:

Colonization with methicillin-resistant

Staphylococcus aureus

(MRSA) poses a hygiene risk that does not spare field hospitals or military medical field camps during military deployments. Diagnostic options for unambiguously identifying MRSA isolates are usually scarce in military environments. In this study

we assessed the stepwise application of two different selective agars for the specific identification of MRSA in screening analyses.

Methods:

Nasal swabs from 1

541 volunteers were subjected to thioglycollate broth enrichment and subsequently screened on CHROMagar MRSA selective agar for the identification of MRSA. The MRSA identity of suspicious-looking colonies was confirmed afterwards or excluded by another selective agar

chromID MRSA. All isolates from the selective agars with MRSA-specific colony morphology were identified by biochemical methods and mass spectrometry.

Results:

The initial CHROMagar MRSA screening identified suspicious colonies in 36 out of 1541 samples. A total of 25 of these 36 isolates showed MRSA-like growth on chromID agar. Out of these 25 isolates

24 were confirmed as MRSA

while one isolate was identified as

Staphylococcus kloosii

. From the 11 strains that did not show suspicious growth on chromID agar

3 were methicillin-sensitive

Staphylococcus aureus

(MSSA

with one instance of co-colonization with

Corynebacterium spp

2 were confirmed as MRSA (with 1 instance of co-colonization with MSSA)

2 were lost during passaging and could not be re-cultured

one could not be identified by the applied approaches

and the remaining 3 strains were identified as

Staphylococcus saprophyticus

Staphylococcus hominis

(co-colonized with

Macrococcus caseolyticus

) and

Staphylococcus cohnii

respectively.

Conclusion:

The application of the selective agar CHROMagar MRSA alone proved to be too non-specific to allow for a reliable diagnosis of the presence of MRSA. The combined use of two selective agars in a stepwise approach reduced this non-specificity with an acceptably low loss of sensitivity. Accordingly

such a stepwise screening approach might be an option for resource-restricted military medical field camps.

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references

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Screening agars for MRSA: evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus (MRSA)

DOI：

摘要

Abstract

关键词

Keywords

references