<正> The changes of skeletal muscle cellular membrane potential（SMCMP）were determined in vivo with the technique of“semi-floating”glass mic-roelectrode in different phases of irreversible hemorrhagic shock in rab-bits.The distribution of extra-and intracellular electrolytes and waterwas studied at the same time.It was found that SMCMP decreased significantly as soon as hypoten-sion occurred

the potential continued to decrease as shock becameprogressively worse

and the leakage of intracellular potassium and reten-tion of intracellular sodium and water occurred 3 hours after the onsetof shock.These facts indicate that the functions of cellular membranebegin to deteriorate in the early stage of shock

the deterioration of thefunctions of the cell proper supervenes as shock progresses

and eventual-ly the cell fails to regulate their volume.