Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis

王肖鹏; 蒋左庶; 胡以平; 程浒君; 杨连生

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Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis

Updated：2026-03-12

- Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis
- Military Medical Research Issue 4, Pages: 387-391(1986)
- Affiliations：
  
  1. Department of Biology Second Military Medical College
  2. ,Shanghai
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1986
- Accepted：
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[1]王肖鹏,蒋左庶,胡以平,程浒君,杨连生.Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis[J].Journal of Medical Colleges of PLA,1986(04):387-391.
DOI：

[1]王肖鹏,蒋左庶,胡以平,程浒君,杨连生.Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis[J].Journal of Medical Colleges of PLA,1986(04):387-391. DOI：

摘要

Abstract

<正> This article is about the effects of interferon（IFN）on sisterchromatid exchange（SCE）frequencies induced by mitomycin C（MMC）and/or unscheduled DNA synthesis（UDS）induced by ultra-violet light（UV）.The result shows that SCE frequencies in peri-pheral lymphocytes from 4 normal individuals and 3 patients withxeroderma pigmentosum（XP）treated with IFN before the additionof MMC were much lower than those of the controls.But after thetreatment of IFN followed by UV irradiation

no difference was fo-und between the UDS levels of the lymphocytes from 2 normal in-dividuals and 2 patients with XP and those from the controls.Thewriters deduce that IFN may have some effect of antimutation

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