Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals

胡友梅; 程天民; 李先珍; 况明书; 朱青平; 刘富安; 吴廷璜

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Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals

Updated：2026-03-12

- Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals
- Military Medical Research Issue 3, Pages: 225-231(1986)
- Affiliations：
  
  1. Department of Pharmacology Third Military Medical College
  2. ,Chongqing
  3. Department of medical protection Department of parasitology
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1986
- Accepted：
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[1]胡友梅,程天民,李先珍,况明书,朱青平,刘富安,吴廷璜.Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals[J].Journal of Medical Colleges of PLA,1986(03):225-231+301.
DOI：

[1]胡友梅,程天民,李先珍,况明书,朱青平,刘富安,吴廷璜.Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals[J].Journal of Medical Colleges of PLA,1986(03):225-231+301. DOI：

摘要

Abstract

<正> The toxic effects of nitroquine-dapsone compound（NQD）in mice and dogs were studied.The therapeutic index of NQDin mice is 1911

the greatest among the 6 antimalarials tested.Thetoxic effects of NQD（50 mg/kg/day for 3 days per os）and nitro-quine in dogs were manifested by injuries on the adrenal cortexand intestinal epithelium.When folic acid（4 mg/kg/day for 4 days）or calcium leucovorinum（0.3 mg/kg/day for 4 days）were usedconcomitantly with NQD

the death rate and the incidence of dia-rrhea in the toxicated dogs were greatly reduced

the injury on theintestinal epithelium was much milder

and the goblet cells weremuch more numerous than those without treatment.The results suggestthat folic acid and calcium leucovorinum can protect the undifferen-tiated cells in the intestinal crypts from being injured by NQD.

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