<正> It was demonstrated that nicorandil 50 and 100 mg/kg intravenously orintraperitoneally could prevent the intoxication of lidocaine and decrease itsmortality rate

furthermore nicorandil 50mg/kg

if combined with 5 mg/kgdiazepam

had a synergetic prophylactic effect against lidocaine toxicity

and thistoxicity could be effectively antagonized by 100 mg/kg of nicorandil in mice.Itwas found that the tolerant dose of lidocaine was elevated by nicorandil 100mg/kg intraperitoneally in rats.