<正> Respiratory distress syndrome was inflicted on 30 dogs with anintravenous injection of oleic acid of the dose 0.06ml/kg. Half of theanimals were treated with anisodamine. Another 5 dogs were injected withsaline to serve as control. The dynamic changes of total hemolyticcomplement activity

neutrophil aggregation rate

platelet aggregation rate

fibrin degradation products

white cell count and platelet count in both theperipheral arterial and venous blood

and blood gas analysis were tested.The pathological and clinical changes were also observed. The results ofthe study suggest that the pathogenesis of respiratory distress syndromewas apparently related to the increase of complement activation

neutrophilaggregating activity

and blood coagulation. The therapeutic effect ofanisodamine can be enhanced if the complement-neutrophil-fibrindegradation products pathway is blocked.