Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice

胡友梅; 聂梅

Your Location：

Home >

Browse articles >

Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice

Updated：2026-03-12

- Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice
- Military Medical Research Issue 2, Pages: 116-119(1989)
- Affiliations：
  
  1. Department of Pharmacology Third Military Medical College
  2. ,Chongqing
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1989
- Accepted：
Scan QR Code
[1]胡友梅,聂梅.Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J].Journal of Medical Colleges of PLA,1989(02):116-119.
DOI：

[1]胡友梅,聂梅.Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J].Journal of Medical Colleges of PLA,1989(02):116-119. DOI：

摘要

Abstract

正

One hundred and ninety-five mice were used to study the mechanism of the protective ef-fects of folic acid on nitroqine toxicity to the small intestine.After oral administration of nitroquineacetate（570mg/kg×1）

intramuscular injection of normal saline was given to one group of mice（NS group）and intramuscular injection of folic acid（8mg/kg×1）to another（NF group）.Decrease incells in the crypts were observed in the animals of NS group

but the changes were much milder inthose of NF group even at 96 h after administration.The decrease of DNA content in the tissues ofthe small intestine was dose-and time-dependent.The value of cpm/mg of DNA after

H-TdRincorporation were much higher in NF group than in NS group.these rcsults suggest that DNA synthesis in the small intestine may be promoted by folic acid so thatthe renair of the damaged intestinal mucosa is acoelerated.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰