On the Chemistry of Pheophorbide a:A Novel Photosensitizer

Hu Longqin Xu Deyu Laboratory for Antimalarial Drug Research; Second Military Medical College; Shanghai

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On the Chemistry of Pheophorbide a:A Novel Photosensitizer

Updated：2026-03-12

- On the Chemistry of Pheophorbide a:A Novel Photosensitizer
- Military Medical Research Issue 2, Pages: 162-166(1987)
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- Published：1987
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[1].On the Chemistry of Pheophorbide a:A Novel Photosensitizer[J].Journal of Medical Colleges of PLA,1987(02):162-166.
DOI：

[1].On the Chemistry of Pheophorbide a:A Novel Photosensitizer[J].Journal of Medical Colleges of PLA,1987(02):162-166. DOI：

摘要

Abstract

正

A method for the preparation of pheophorbide a（a novel photosensiti-zer for tumor photolocalization and photodynamic therapy）from silkwormexcrement oily chlorophyll is reported.The chromatographic

spectroscopic andphotochemical properties of pheophorbide a were studied

and its distribution intissues of S180 tumor-bearing mice was determined.The UV/visspectrum of the obtained pheophorbide a was identical with thatreported by other authers

but it was still found to contain at least twocomponents（probably two optical isomers）by HPLC analysis and

H-NMR spectrometry.The results of a preliminary study on itsdistribution in tumor-bearing mice showed that it was accumulatedselectively in tumor tissues after intravenous injection and at 24 hoursafter drug administration the tumor to skin ratio rose to as high as 15.

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