<正> The relationship between gastric mucosal blood flow （GMBF） and gastric acid secretionwere studied in rats by using secretory stimulant （pentagastrin）and inhibitor（cimetidine）. GMBFwas measured by Laser Doppler flowmetry （LDF） and gastric mucosal pH determined by microglasspH electrode. GMBF increased and gastric mucosal pH decreased significantly after intravenous injec-tion of 6μg/kg of pentagastrin; nevertheless GMBF decreased and gastric mucosal pH increasedmarkedly after intravenous administration of 100mg/kg of cimetidine. This indicates that pentagastrincan increase GMBF and gastric acid secretion

and cimetidine can decrease GMBF and gastric acidsecretion in rats

proving the close relationship between GMBF and gastric acid secretion in rats.