In Vitro Induction of AFP-Specific Plaque-Forming Cells by Heterogeneic Immune RNA

吉昌华; 王成济; 苏成芝

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In Vitro Induction of AFP-Specific Plaque-Forming Cells by Heterogeneic Immune RNA

Updated：2026-03-12

- In Vitro Induction of AFP-Specific Plaque-Forming Cells by Heterogeneic Immune RNA
- Military Medical Research Issue 4, Pages: 368-370(1989)
- Affiliations：
  
  1. Department of Biochemistry Fourth Military Medical University
  2. ,Xi’an,710033
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1989
- Accepted：
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[1]吉昌华,王成济,苏成芝.In Vitro Induction of AFP-Specific Plaque-Forming Cells by Heterogeneic Immune RNA[J].Journal of Medical Colleges of PLA,1989(04):368-370.
DOI：

[1]吉昌华,王成济,苏成芝.In Vitro Induction of AFP-Specific Plaque-Forming Cells by Heterogeneic Immune RNA[J].Journal of Medical Colleges of PLA,1989(04):368-370. DOI：

摘要

Abstract

<正> In the present study

AFP-specific immune RNA（iRNA） was shown to induceplaque-forming cells（PFC）from mouse splenocytes with a minimal effective dose of 31 μg/mland an optimal dose plateau ranging from 125 μg/ml to 250 μg/ml.This action of iRNA may beobserved on the first day of in vitro culture of mouse spleen cells.The iRNA preparation wasproved sensitive to RNase

but not to DNase and pronase.In addition immunofluorescencetest revealed that AFP-specific iRNA is capable of inducing the expression of membranousanti-AFP antibodies or AFP receptors in mouse spleen cells.

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