<正> By using silver colloid staining technique

nucleolar organizer region-associated proteins（AgNORs）were studied quantatively in paraffin sections of 12 casesof polypoid adenomas

10 cases of villous adenomas

22 cases of colonadenocarcinomas

and 10 cases of normal colonic mucosa as control.The resultsshowed that the mean number of AgNORs per nucleus in the villous adcnoma was similarto that of adenocaranoma

which significantly exceeded those of the normal mucosa andthe polypoid adenoma.The granules of AgNORs in adcnocarcinoma were much largerand more irregular in sizc and shape.It is suggested that benign villous adenoma is akind of lesion between polypoid adenoma and adenocarcinoma

and AgNOR techniquemay be very helpful in differential diagnosis of colon tumors.