<正> The changes of sclenium metabolism

glutathione peroxidase activity and lipid peroxidescontent in the tissues of rats suffering from 30% TBSA full thickness scalding were observed in thefirst 7 days after injury. It was found that selenium content in the rat tissues decreased remarkably af-ter injury

which in turn resulted in serious reduction of glutathione peroxidasc activity and significantincrease of lipid peroxides in the scrum

crythrocytcs and liver. However the muscular tissue showedno significant changes. These facts imply that after burn injury

the body is in a state of selenium deficiency

the lossof selenium might be responsible for the reduction of anti - peroxidation ability of glutathioneperoxidase

and conscqucntly there is an increase of lipid peroxides in the tissues. Only the musculartissue is insensitive to lipid peroxidation. It is believed that the reduction of anti-peroxidation abilityof glutathione peroxidasc after bum injury might be one of the main causes to intensify

the injury re-suiting from free radicals.