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The changes of the ultrastructure and the cellular permeability of Candida albicans were ob-served after the fungus was exposed to 3%～10% hydrogen peroxide.Damages on the fungus cellsespecially cytoplasm leakage were found under transmission electron microscopy and morphologicalchanges with small hole-like structures under scanning dectron microcopy.Radioactivity assay ofthe leakage of [

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H]-TdR-DNA of C.albicans further proved the existence of cellular permeabilitydamage.There was negative correlation between the amount of [

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H-TdR-DNA leakage and thenumber of the survival fungus cells

which indicates that the damage on cellular permeability andDNA leakage caused by hydrogen peroxide of certain concentration is one of the important factorsto kill the fungus.