Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig

罗晓星; 谭月华

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Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig

Updated：2026-03-12

- Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig
- Military Medical Research Issue 1, Pages: 68-73(1991)
- Affiliations：
  
  1. Department of Pharmacology Fourth Military Medical University
  2. ,Xi’an,710032
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1991
- Accepted：
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[1]罗晓星,谭月华.Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig[J].Journal of Medical Colleges of PLA,1991(01):68-73.
DOI：

[1]罗晓星,谭月华.Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig[J].Journal of Medical Colleges of PLA,1991(01):68-73. DOI：

摘要

Abstract

正

The purpose of these experiments was to investigate the possible ionicbases for ranitidine （Ran） in isolated papillary muscles of the guinea pig.Ran

when the concentration was below 300μmol/L

had no influence on contraction ofnormal muscles and only above 0.3 mmol/L

it showed weak negative inotropic ef-fect.The contractile activity elicited by histamine in potassium depolarized mus-cles was depressed by Ran markedly and dose-dependently.The IC

of Ran was0.273μmol/L.This depressant effect was reversed by an elevation of externalCa

concentration to 7.7mmol/L.The contraction induced by isoproterenol inpotassium depolarized preparations was not altered by Ran.Ran at theconcentrations of 1

10 and 100μmol/L failed to show influences on fast actionpotentials.However

Ran at 0.5μmol/L time-dependently inhibited slow action po-tentials.It is concluded that the ionic mechanism of Ran might be attributed toantagonized H

receptor of myocardium which in turn decreases Ca

inward cur-rent.

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