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In the present study

an anti-gastric cancer monoclonal antibody MGb

2

-daunomycin（DM）conjugate was prepared by cis-aconitic anhydride method.The distribution of the conjugatein nude mice bearing human gastric carcinoma SGC-7901 was investigated.Four to five moleculesof DM were introduced into each molecule of antibody while the antigen-binding capacity ofthe antibody was well-retained.This conjugate could be satisfactorily localized in the tumortissue.Ninety-six hours after intraperitoneal injection of

125

I-MGb

2

-DM conjugate

the ratio ofradioactivity per milligram of tumor to that per milligram of blood reached 203

the result beingquite similar to that of unmodified MGb

2

.