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In this report

a comparative study is made of the function test of spontaneousT suppressor cell（STs）and T Lymphocyte subsets in patients with epidemic hemorrha-gic fever（EHF）.It was found that in the early stages of the disease the activity of STs wasmarkedly lower than that of the controls

while the percentage of CD

?

+

cells increasedsignificantly

which led to the decrease and reciprocation of CD

4

/CD

8

ratio

and that theactivity of STs was reversely related to the proportion of CD

8

+

cells on linear regressionanalysis

indicating that the CD

8

+

cells increased may mainly belong to cytotoxic T cells.It was also shown that the changes of STs function and CD

4

/CD

8

ratio were related tothe abnormalities of serum C

3

content and circulating immune complex.The results sug-gest that the disturbance of host cellular immunoregulation may play an important rolein the pathogenesis of EHF.