The expression of the products of IGF-Ⅱ,IGF-Ⅱ receptors and CSF-Ⅰ receptors in human primary hepatocellular carcinoma and juxtacancerous liver tissue

杨冬华; 刘为纹; 顾健人; 刘尚廉

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The expression of the products of IGF-Ⅱ,IGF-Ⅱ receptors and CSF-Ⅰ receptors in human primary hepatocellular carcinoma and juxtacancerous liver tissue

Updated：2026-03-12

- The expression of the products of IGF-Ⅱ,IGF-Ⅱ receptors and CSF-Ⅰ receptors in human primary hepatocellular carcinoma and juxtacancerous liver tissue
- Military Medical Research Issue 4, Pages: 368-376(1993)
- Affiliations：
  
  1. Department of Gastroenterology Southwest Hospital
  2. Third Military Medical College
  3. ,Shanghai,200032
  4. National Research Center for Oncogenes and Related Genes of Shanghai
  5. Department of Pathology
  6. Tumor Hospital
  7. First Shanghai Medical University
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1993
- Accepted：
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[1]杨冬华,刘为纹,顾健人,刘尚廉.The expression of the products of IGF-Ⅱ,IGF-Ⅱ receptors and CSF-Ⅰ receptors in human primary hepatocellular carcinoma and juxtacancerous liver tissue[J].Journal of Medical Colleges of PLA,1993(04):368-376.
DOI：

[1]杨冬华,刘为纹,顾健人,刘尚廉.The expression of the products of IGF-Ⅱ,IGF-Ⅱ receptors and CSF-Ⅰ receptors in human primary hepatocellular carcinoma and juxtacancerous liver tissue[J].Journal of Medical Colleges of PLA,1993(04):368-376. DOI：

摘要

Abstract

<正> The expression of the products of IGF-Ⅱ

IGF-Ⅱ receptors（IGF-Ⅱ-R）and CSF-Ⅰ re-ceptors（CSF-Ⅰ-R）was observed in 17 cases of human primary hepatocellular carcinoma（PHC）and the juxtacancerous liver tissue with immunohistochemistry（ABC）

Western blot and North-ern blot technique

It was found that the expression of IGF-Ⅱ

IGF-Ⅱ-R and CSF-Ⅰ-R was signif-icantly higher in PHC than in normal liver tissue and the expression of IGF-Ⅱ and IGF-Ⅱ-R wasremarkably higher in the juxtacancerous liver tissue from PHC patients than in PHC proper.Itwas noteworthy that the expression of IGF-Ⅱ in both the cancer proper and the juxtacancerousliver tissue was characterized by its fetal type.Besides

the expression of CSF-Ⅰ-R was signifi-cantly higher in PHC than in the juxtacancerous liver tissue.It is believed that the abnormal ex-pression of IGF-Ⅱ

IGF-Ⅱ-R and CSF-I-R in PHC and the juxtacaneerous liver tissue might berelated to the autocrine mechanism of human PHC.

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