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We have previously shown that the lipofuscin in the brain seems to have in-creased in amount in autopsy cases of epidemic hemorrhagic fever.The purpose of thisstudy was to testify if there is really such an increase.Lipfuscin in 10 sections from everybrain of 10 autopsy cases

stained with Sudan Ⅳ

Sudan black and H.E.

was carefully es-timated and found to be greatly increased as compared with the controls of the same agewithout brain disease.Animal experiment was also conducted on 15 sucking BALB/c miceby I.P.inoculation of 100 LD

50

（0.05ml）of strain Chen of hemorrhagic fever virus

andon 15 mice without inoculation as controls.No lipofuscin was detected in the controls.However

in the brains of experimental mice

lipofuscin was found to be markedly in-creased

especially in the necrotic cells.The findings suggest that the over-productionand deposition of lipofuscin may be a mild change caused by the virus and its related fac-tors

which might be enhanced by hypotension and shock.