Influence of partially purified lymphocyte chalone on bone marrow transplantation in mice

耿怡; 麦智广; 丁振海; 张进

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Influence of partially purified lymphocyte chalone on bone marrow transplantation in mice

Updated：2026-03-12

- Influence of partially purified lymphocyte chalone on bone marrow transplantation in mice
- Military Medical Research Issue 2, Pages: 187-191(1992)
- Affiliations：
  
  Department of Radiation Medicine Second Military Medical University Shanghai,200433
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- Published：1992
- Accepted：
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[1]耿怡,麦智广,丁振海,张进.Influence of partially purified lymphocyte chalone on bone marrow transplantation in mice[J].Journal of Medical Colleges of PLA,1992(02):187-191.
DOI：

[1]耿怡,麦智广,丁振海,张进.Influence of partially purified lymphocyte chalone on bone marrow transplantation in mice[J].Journal of Medical Colleges of PLA,1992(02):187-191. DOI：

摘要

Abstract

正

Lymphocyte chalone was partially purified by ultrafiltration and chromatography onSep hadex G75 column.Its inhibitory effect on proliferation of T

B lymphoctes was demonstratedby[

H]-TdR incorporation method.In mouse bone marrow transplantation model

the treatmentwith lymphocyte chalone in vivo and in vitro was found to have significantly improved the 30 daysurvival rate and mean survival time

suggesting its inhibitory effect on acute graft-versus-host dis-ease（GVHD）and the helpful effect on H-2 incompatible tone marrow transplantation in mice.

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