Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）

沈念慈; 袁伯俊; 唐惠兰; 李保春; 刘俊平; 李燕平; 张璞

Your Location：

Home >

Browse articles >

Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）

Updated：2026-03-12

- Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）
- Military Medical Research Issue 3, Pages: 215-221(1990)
- Affiliations：
  
  1. Laboratory for Antimalarial Drug Research and Department of Pathologic Anatomy
  2. Second Military Medical University Shanghai,200433
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1990
- Accepted：
Scan QR Code
[1]沈念慈,袁伯俊,唐惠兰,李保春,刘俊平,李燕平,张璞.Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin(PsD-007)[J].Journal of Medical Colleges of PLA,1990(03):215-221+226.
DOI：

[1]沈念慈,袁伯俊,唐惠兰,李保春,刘俊平,李燕平,张璞.Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin(PsD-007)[J].Journal of Medical Colleges of PLA,1990(03):215-221+226. DOI：

摘要

Abstract

正

Photocarcinorin was prepared in our Lab and its composition was differentfrom that of any other hematoporphyrin photosensitizers by TLC and HPLC analyses.The 95% fiducial limits of iv LD in mice were 176-236 mg·kg

-1

.The iv MLD indogs was 171 mg·kg

-1

.The acute and subacutc toxic tests in 37 dogs showed that theintoxicated manifestations were characterized by a complex syndrome always seen inporphyrias.The biological

laboratory and histopathologic findings revealed that theliver

kidney and erythroeytic series were the target organs.The damages were dose-related and reversible within 2 wk.he phototoxicity was determined in mice with UV ra-diation and compared with that of HpD.The extent of its phototoxic reactions waslower than that of HpD’s.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰