<正> The effects of somatostatin and cysteamine injected into theventromedial nucleus of hypothalamus（VMH）on somatostatin-likeimmunoreactivity（SLI）concentration in the gastric antral mucosa and portal veinplasma

as well as the gastric acid secretion were studied in anesthetized rats.TheSLI concentration in the gastric antral mucosa and portal vein plasma and thegastric acid output were significantly increased one hour after the injection ofsomatostatin（0.5μg/0.5μ1）into the VMH.Four hours later

the SLI concentrationin the mucosa was still higher than the control level

while the SLI level in theplasma and the acid secretion were close to those of controls.On the contrary

the SLI concentration in the mucosa and plasma and the acid output weremarkedly decreased at four hours after the injection of cysteamine（15μg/0.5μ1）into the VMH.The present results suggest that both exogenous and endogenoussomatostatin in the VMH have a facilitatory action on the gastric somatostatinconcentration and its release as well as on the gastric acid secretion

thus provid-ing evidence for hypothalamic control of gastric somatostatin and acid secretion.