<正> The results of research work completed in recent years in the authors’ laboratory withmonoclonal antibodies （McAbs） against herpes simplex virus （HSV） are reported in this paper as fol-lows.（1） Eighteen hybridoma cell lines steadily producing McAbs against HSV were established byhybridoma technic.（2） The mechanisms of neutralization in vitro and animal protection in vivo medi-ated by different McAbs were investigated.（3） A method of detecting virus antigua was developedwith the McAbs.（4） Tne isolates of virus were typed and antigenically analysed by type-specificand type-common McAbs.（5） HSV antigen in clinical spectimens was detected and directly typed byan ELISA method coating with type-specific and type-common McAb.（6） The target antigens ofMcAbs were identified

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and their genes were localized.（7） Experimental rabbitHSV keratitis was treated with McAbs.