Clinical study of applying fructose-1,6-diphosphate and captopril to enhance the protective effects of cardioplegia solution on ischemic myocardium

李彤; 刘维永; 杨景学; 梁继河; 易定华; 汪钢; 刘宗贵; 方福珍; 王伟宪

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Clinical study of applying fructose-1,6-diphosphate and captopril to enhance the protective effects of cardioplegia solution on ischemic myocardium

Updated：2026-03-12

- Clinical study of applying fructose-1,6-diphosphate and captopril to enhance the protective effects of cardioplegia solution on ischemic myocardium
- Military Medical Research Issue 4, Pages: 342-348(1993)
- Affiliations：
  
  1. Department of Cardiovascular and Thoracic Surgery Xijing Hospital
  2. Fourth Military Medical University
  3. ,Xi’an,710032
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1993
- Accepted：
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[1]李彤,刘维永,杨景学,梁继河,易定华,汪钢,刘宗贵,方福珍,王伟宪.Clinical study of applying fructose-1,6-diphosphate and captopril to enhance the protective effects of cardioplegia solution on ischemic myocardium[J].Journal of Medical Colleges of PLA,1993(04):342-348.
DOI：

[1]李彤,刘维永,杨景学,梁继河,易定华,汪钢,刘宗贵,方福珍,王伟宪.Clinical study of applying fructose-1,6-diphosphate and captopril to enhance the protective effects of cardioplegia solution on ischemic myocardium[J].Journal of Medical Colleges of PLA,1993(04):342-348. DOI：

摘要

Abstract

正

In the present experiment

fructose-1

6-diphosphate（FDP）and captopril（Cap）wereadded to the cold potassium cardioplegia solution and the levels of malondialdehyde（MDA）

cre-atine phosphokinase MB（CPK-MB）

thromboxane B（TXB

）and 6-keto-PGF

1α

in plasma weremeasured during open-heart surgery.Quantitative study of myocardial ultrastructure and obser-vation of cardiac resuscitation were also undertaken.The findings suggested that FDP

especiallywhen combined with Cap could significantly strengthen the protective effects of cold potassiumcardioplegia solution on ischemic myocardium.

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