<正> Estrogen and progesterone receptor （ER and PR） contents of 40 breastcancer patients were determined with immunofluorescent staining.Thedifferentiation of cancer cells was evaluated on the basis of histological andultrastructural changes.It was found that there was a positive correlation of ERand PR contents with the cellular differentiation of breast cancer

and the lattercould be used to estimate the status of hormone receptors.Breast cancer is a malignant disease with heteropathological characteristics.In handling a breast cancerpatient

both the status of hormone receptors and the cellular differentiationshould be considered and the treatment varied with each pa（?）ent.For those witha well-differentiated cancer and rich hormone receptors

endocrine therapy shouldmainly be administered

while for those with a poorly-differentiated cancer and afew hormone receptors

chemotherapy would be of choice.