Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats
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Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats
Military Medical ResearchIssue 1, Pages: 49-51(1992)
Affiliations:
1. Department of Pharmacology First Military Medical University
2. ,Guangzhou,510515
Author bio:
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DOI:
CLC:
Published:1992
Accepted:
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[1]张永胜,张家新,余传林,刘菊芳.Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats[J].Journal of Medical Colleges of PLA,1992(01):49-51.
DOI:
[1]张永胜,张家新,余传林,刘菊芳.Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats[J].Journal of Medical Colleges of PLA,1992(01):49-51.DOI:
Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats
摘要
Abstract
<正> Microinjection of 0.5μg guanabenz(GB)into the nucleus tractus solitarii(NTS)orintravenous(i.v.)injection of 10μg/kg of GB significantly lowered plasma renin activity(PRA).blood pressure(BP)and heart rate(HR)in rats i.v.10 μg/kg GB
after the bilateral NIS were de-stroyed by electric current(1 mA 20s)
did not decrease PRA
BP and HR.These findings suggestthat the inhibitory action of GB on PRA
BP and HR is related to the activation of alpha-2adrenoceptors in the NTS.
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